甲型流感-话题@MedSci

#甲型流感#

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[GetTopicListResponse(id=2162503, encodeId=0bb3216250352, content=<a href='/topic/show?id=021b65306fb' target=_blank style='color:#2F92EE;'>#流感#</a> 流感新药<a href='/topic/show?id=93de1069216d' target=_blank style='color:#2F92EE;'>#速福达#</a>，即<a href='/topic/show?id=d6bf10421363' target=_blank style='color:#2F92EE;'>#玛巴洛沙韦#</a>，整个疗程一粒搞定。不过国内也开始有me too和me better相关产品，如<a href='/topic/show?id=e8f828584fd' target=_blank style='color:#2F92EE;'>#先声药业#</a>宣布已与安谛康就抗流感创新药<a href='/topic/show?id=dbdc106922ba' target=_blank style='color:#2F92EE;'>#ADC189#</a>订立合作协议。ADC189是一种抗流感的聚合酶酸性蛋白（PA）抑制剂，通过抑制流感病毒中的CAP帽状-依赖型核酸内切酶（CEN），ADC189可直接抑制流感病毒的复制，对抗<a href='/topic/show?id=244169e70f0' target=_blank style='color:#2F92EE;'>#甲型流感#</a>和<a href='/topic/show?id=7ad6233921a' target=_blank style='color:#2F92EE;'>#乙型流感#</a>病毒。临床前研究显示，ADC189具有无中枢神经系统副作用、口服吸收不受食物影响、更高安全剂量等优势ADC189全程口服剂量仅为“一粒”，并可在24小时内阻止流感病毒复制，目前，ADC189治疗流感3期临床试验正推进中。 <a href='/topic/show?id=a22410692356' target=_blank style='color:#2F92EE;'>#石药欧意#</a>的玛巴洛沙韦<a href='/topic/show?id=b56025592eb' target=_blank style='color:#2F92EE;'>#仿制药#</a>，目前仍然有很多争议，估计会与<a href='/topic/show?id=4c2ce960918' target=_blank style='color:#2F92EE;'>#罗氏#</a>打官司。 <a href='/topic/show?id=273b106924eb' target=_blank style='color:#2F92EE;'>#众生睿创#</a><a href='/topic/show?id=2a57106925f1' target=_blank style='color:#2F92EE;'>#ZSP1273#</a>（<a href='/topic/show?id=46f11069269b' target=_blank style='color:#2F92EE;'>#昂拉地韦#</a>）片及颗粒、<a href='/topic/show?id=ffaf10692e20' target=_blank style='color:#2F92EE;'>#珍宝岛药业#</a>/广州市<a href='/topic/show?id=6d87106928bc' target=_blank style='color:#2F92EE;'>#恒诺康医药#</a>的注射用HNC042、<a href='/topic/show?id=833e106929df' target=_blank style='color:#2F92EE;'>#青峰医药#</a>/<a href='/topic/show?id=9f401069306c' target=_blank style='color:#2F92EE;'>#银杏树#</a>的GP681、<a href='/topic/show?id=530710693126' target=_blank style='color:#2F92EE;'>#太景医药#</a>/健康元核酸内切酶抑制剂TG-1000（已授权给<a href='/topic/show?id=b15c2e754f7' target=_blank style='color:#2F92EE;'>#健康元#</a>）、<a href='/topic/show?id=0f61106932d2' target=_blank style='color:#2F92EE;'>#征祥医药#</a>/济川药业的抗流感新药ZX-7101A（已授权给<a href='/topic/show?id=42aa1069339e' target=_blank style='color:#2F92EE;'>#济川药业#</a>，ZX-7101A的EC50达纳摩尔级,与BXM活性形式巴洛沙韦酸(BXA)相当）等，都可以说是玛巴洛沙韦的me too产品。未来还要看哪些药物最终可以上市，以及使用的疗效和方便性，以及能否有幼儿的适应症（主要与安全有关），这些都直接影响到市场规模。, objectTitle=流感, objectType=topic, longId=65306, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020122/1606873539905_4754896.png, objectUrl=null, replyNumber=0, likeNumber=146, createdTime=2023-10-13, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=0, attachment=null, ipAttribution=上海, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2119010, encodeId=ed83211901007, content=<a href='/topic/show?id=244169e70f0' target=_blank style='color:#2F92EE;'>#甲型流感#</a>后面应该开发多价<a 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lengthMark=0)] 梅斯话题小助手

甲型流感

2020-05-29

侠胆医心 (审核中...)

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全文收起 #流感# 流感新药#速福达#，即#玛巴洛沙韦#，整个疗程一粒搞定。不过国内也开始有me too和me better相关产品，如#先声药业#宣布已与安谛康就抗流感创新药#ADC189#订立合作协议。ADC189是一种抗流感的聚合酶酸性蛋白（PA）抑制剂，通过抑制流感病毒中的CAP帽状-依赖型核酸内切酶（CEN），ADC189可直接抑制流感病毒的复制，对抗#甲型流感#和#乙型流感#病毒。临床前研究显示，ADC189具有无中枢神经系统副作用、口服吸收不受食物影响、更高安全剂量等优势ADC189全程口服剂量仅为“一粒”，并可在24小时内阻止流感病毒复制，目前，ADC189治疗流感3期临床试验正推进中。 #石药欧意#的玛巴洛沙韦#仿制药#，目前仍然有很多争议，估计会与#罗氏#打官司。 #众生睿创##ZSP1273#（#昂拉地韦#）片及颗粒、#珍宝岛药业#/广州市#恒诺康医药#的注射用HNC042、#青峰医药#/#银杏树#的GP681、#太景医药#/健康元核酸内切酶抑制剂TG-1000（已授权给#健康元#）、#征祥医药#/济川药业的抗流感新药ZX-7101A（已授权给#济川药业#，ZX-7101A的EC50达纳摩尔级,与BXM活性形式巴洛沙韦酸(BXA)相当）等，都可以说是玛巴洛沙韦的me too产品。未来还要看哪些药物最终可以上市，以及使用的疗效和方便性，以及能否有幼儿的适应症（主要与安全有关），这些都直接影响到市场规模。

2023-10-13发表于上海

侠胆医心 (审核中...)

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#甲型流感#后面应该开发多价#流感疫苗#+#新冠病毒疫苗#+#RSV疫苗#综合疫苗，这样一针就能预防多种#病毒感染#了

Science:甲流病毒中和抗体被发现

2023-03-12发表于上海

redcrab (审核中...)

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#甲型流感#

甲型流感来势汹汹，专家表示群体免疫下降，口罩增加了易感人群

2022-06-27

redcrab (审核中...)

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#甲型流感#

广州荔湾区通报市**中学高中部甲型流感疫情，病例已增至百人以上

2019-12-15

redcrab (审核中...)

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#甲型流感#

新型甲型流感疫苗进入IIb期试验

2019-06-13

redcrab (审核中...)

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#甲型流感#

JCLA：甲型流感病毒通过诱导IL‐37抑制流感病毒复制

2019-06-03

redcrab (审核中...)

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#甲型流感#

Cell Discovery：甲型流感病毒治疗性抗体研究方面取得进展

2019-04-25

redcrab (审核中...)

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#甲型流感#

J Virol：科学家发现甲型流感病毒M2蛋白顶端靶点在病毒复制中具有重要作用

2018-11-15

redcrab (审核中...)

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#甲型流感#

PLoS One：研究揭示大黄酸抗甲型流感病毒活性的机制

2018-04-15

redcrab (审核中...)

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#甲型流感#

警惕！甲型流感取代乙型流感，多地高发！

2018-01-28

redcrab (审核中...)

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#甲型流感#

万能疫苗现世！科学家制出抗甲型流感万能疫苗

2018-01-28

redcrab (审核中...)

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#甲型流感#

Clin Exp Allergy：在过敏性鼻粘膜中，类型III干扰素是决定对甲型流感病毒感染敏感的宿主因素

2018-01-18

redcrab (审核中...)

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#甲型流感#

NEJM：甲型流感病毒感染相关的纵隔气肿-病例报道

2018-01-05

redcrab (审核中...)

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#甲型流感#

Sci Rep：不只健胃整肠！乳酸菌还能预防甲型流感病毒

2017-12-17

redcrab (审核中...)

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#甲型流感#

Sci Rep：于广利课题组发现褐藻硫酸多糖KW抑制甲型流感病毒感染

2017-05-01

redcrab (审核中...)

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#甲型流感#

香港一小学爆发甲型流感 20人受影响目前情况稳定

2017-03-10

redcrab (审核中...)

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#甲型流感#

isterra正式启动甲型流感药物VIS410的2期临床试验

2017-01-18

redcrab (审核中...)

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#甲型流感#

严密监控H7N9甲型流感病毒很重要

2013-07-12

redcrab (审核中...)

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#甲型流感#

医学专家发现甲型流感重症易感基因干扰素诱导的跨膜蛋白－3基因

2013-05-08

redcrab (审核中...)

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#甲型流感#

PLOS ONE:甲型流感病毒进化和传播规律研究获进展

2013-03-09

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