Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today s clinical laboratory. In addition to being the most cited journal in the field (over 18,000 citations in 2005), Clin Chem has the highest Impact Factor (7.717 in 2005) among journals of clinical chemistry, clinical (or anatomic) pathology, analytical chemistry, and the subspecialties, such as transfusion medicine, clinical microbiology. The journal issued monthly, publishes contributions, either experimental or theoretical, that concern basic materials or principles, analytical and molecular diagnostic techniques, instrumentation, data processing, statistical analyses of data, clinical investigations in which chemistry has played a major role, or laboratory animal studies of chemically oriented problems of human disease.