ICSI和传统IVF患者妊娠结局和后代先天畸形有差异吗？
2025-03-21 生殖医学论坛 生殖医学论坛 发表于陕西省
探讨卵胞浆内单精子注射(ICSI)与传统体外受精(IVF)相比是否会增加胎儿和活产儿畸形的风险。
Objective
目的
To explore whether intracytoplasmic sperm injection (ICSI) would increase the malformation risk in fetuses and live births compared with conventional in vitro fertilization (IVF).
探讨卵胞浆内单精子注射(ICSI)与传统体外受精(IVF)相比是否会增加胎儿和活产儿畸形的风险。
Design
设计
Retrospective cohort study.
回顾性队列研究。
Patient(s)
患者
Data were collected from couples who underwent conventional IVF or ICSI from January 2009 to December 2019 at the Center for Reproductive Medicine of Peking University Third Hospital in the People’s Republic of China. A total of 46,167 conventional IVF fresh transfer cycles and 33,247 ICSI fresh transfer cycles were included.
数据来自 2009 年 1 月至 2019 年 12 月在中国北京大学第三医院生殖医学中心接受传统IVF或ICSI助孕的夫妇。共纳入 46167 个传统IVF鲜胚移植周期和 33247个ICSI鲜胚移植周期。
Intervention(s)
干预措施
Intracytoplasmic sperm injection and conventional IVF.
卵胞浆内单精子注射和传统IVF。
Main Outcome Measure(s)
主要结果测量
The primary outcomes were congenital abnormalities in live births. The secondary outcomes included the pregnancy outcomes, the malformations among the miscarriages, specific types of malformations in live births, birth weight, and sex.
主要结果是活产儿的先天畸形。次要结果包括：妊娠结局、流产儿的畸形、活产儿的具体畸形类型 、出生体重和性别。
Result(s)
结果
The rates of congenital malformations in conventional IVF and ICSI were 5.44‰ and 5.78‰, respectively. There was no statistically significant difference between the two groups, as indicated by the adjusted odds ratio of 1.098 (95% confidence interval 0.787, 1.532). The rates of specific malformations were comparable between ICSI and IVF. Additionally, no discernible disparities were noted in pregnancy outcomes, the malformations among the miscarriages,birth weight between the two groups.
传统IVF和ICSI的先天畸形发生率分别为 5.44‰和 5.78‰。两组之间没有统计学的显著差异，调整比值比为1.098(95%置信区间 0.787，1.532)。ICSI和IVF之间的特定畸形发生率相当。此外，两组之间的妊娠结果、流产儿的畸形、出生体重没有明显差异。
Conclusion
结论
Our study suggested the safety of ICSI and provided novel evidence by comparing pregnancy outcomes and congenital malformations in offspring between patients undergoing conventional IVF and ICSI.
我们的研究表明ICSI技术是安全的，并通过比较接受传统 IVF 和ICSI的患者的妊娠结果和后代先天畸形为ICSI技术的安全性提供了新的证据。
参考文献：
A comparison of pregnancy outcomes and congenital malformations in offspring between patients undergoing intracytoplasmic sperm injection and conventional in vitro fertilization: a retrospective cohort study Zhang, Nan et al.Fertility and Sterility, Volume 121, Issue 6, 982 - 990
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在此留言
#体外受精# #卵胞浆内单精子注射#
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