2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety

Dow, RL; Ammirati, M; Bagley, SW; Bhattacharya, SK; Buckbinder, L; Cortes, C; El-Kattan, AF; Ford, K; Freeman, GB; Guimaraes, CRW; Liu, SP; Niosi, M; Skoura, A; Tess, D

Dow, RL (reprint author), Pfizer Worldwide Res & Dev, Cambridge, MA 02139 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (7): 3114

Abstract

Studies have linked the serine-threonine kinase MAP4K4 to the regulation of a number of biological processes and/or diseases, including diabetes, canc......

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