The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors

Smith, GP; Badolo, L; Chell, V; Chen, IJ; Christensen, KV; David, L; Daechsel, JA; Hentzer, M; Herzig, MC; Mikkelsen, GK; Watson, SP; Williamson, DS

Smith, GP (reprint author), H Lundbeck & Co AS, Ottiliavej 9, DK-2500 Valby, Denmark.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (18): 4500

Abstract

Leucine-rich repeat kinase 2 (LRRK2) has attracted considerable interest as a therapeutic target for the treatment of Parkinson's disease. Compounds d......

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