Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker

Do, HT; Wang, HY; Li, HY; Chreifi, G; Poulos, TL; Silverman, RB

Silverman, RB (reprint author), Northwestern Univ, Chem Life Proc Inst, Ctr Mol Innovat & Drug Discovery, Dept Chem,Dept Mol Biosci,Ctr Dev Therapeut, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Poulos, TL (reprint author), Univ Calif Irvine, Dept Mol Biol

JOURNAL OF MEDICINAL CHEMISTRY, 2017; 60 (22): 9360

Abstract

Inhibition of neuronal nitric oxide synthase (nNOS) is a promising therapeutic approach to treat neurodegenerative diseases. Recently, we have achieve......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索