Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect

Cheng, AX; Zhang, P; Wang, B; Yang, DD; Duan, XT; Jiang, YL; Xu, T; Jiang, Y; Shi, JH; Ding, CT; Wu, G; Sang, ZH; Wu, Q; Wang, H; Wu, M; Zhang, ZY; Pan, X; Pan, YY; Gao, P; Zhang, HF; Zhou, CZ; Guo, J; Yang, ZY

Guo, J; Yang, ZY (reprint author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Innate Immun & Chron Dis, Affiliated Hosp 1,Div Life Sci & Med, Hefei, Anhui, Peoples R China.

NATURE COMMUNICATIONS, 2019; 10 ():

Abstract

Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether Aurora-A is also involved in metabolic reprogramming-mediate......

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