Arthritis Rheumatol:什么水平的炎症会引起骶髂关节结构性损伤?

2019-07-22 xiangting MedSci原创

虽然广泛性SIJ BMO是出现结构性病变强有力的独立预测因子,但局限性/中等BMO大多为短暂性的,很少发展为广泛性BMO或结构性病变。

骶髂关节(SIJ)骨髓水肿(BMO)被认为是识别早期脊柱关节炎的关键。然而,BMO与脊柱关节炎相关骨重塑进展之间的关联尚不清楚。这项研究目的是探讨SIJs中BMO和结构病变随时间的演变。

对604名年龄18-40岁的患者进行基线和4年随访MRI检查,这些患者因腰痛至脊柱门诊就诊。对8个SIJ区域的BMO进行评分,评分包括:不存在、局限性(<25%的皮质下骨区域)、中等(25-50%)或广泛性(>50%)。结构性病变包括侵蚀和脂肪病变,评为不存在/存在。

41%的参与者在任一时间点有SIJ BMO,但只有16%的参与者两个时间点均有SIJ BMO。根据BMO的基线程度出现结构性SIJ病变:基线局限性/中等/广泛性 BMO(与不存在相比)与随访时的侵蚀独立相关,优势比(ORs)为3/5/46,脂肪病变的ORs分别为3/7/33。基线时局限性和中等BMO区域中的60%和50%缓解,而在随访中只有2%和7%发展为广泛性BMO。

虽然广泛性SIJ BMO是出现结构性病变强有力的独立预测因子,但局限性/中等BMO大多为短暂性的,很少发展为广泛性BMO或结构性病变。这些发现强化了人们对SIJ病变自然发展的理解,并指出了局限性/中等vs.广泛性BMO的不同进展模式可能是由不同病因引起的。

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