Semin Arthritis Rheu:慢性背痛的结节病患者中脊柱关节炎的患病率高

2019-03-14 xiangting MedSci原创

炎性背痛的结节病患者中SpA的患病率升高。   这项横断面研究纳入了64例诊断为结节病的CBP患者。主诉CBP的患者接受完整的脊柱MRI和X线摄影。所有的炎

慢性背痛(CBP)是结节病患者的常见主诉,由于该症状可能由多重原因导致,这对临床医生提出了挑战。有趣的是,一些报道表明结节病和脊柱关节炎(SpA)共存很常见。这项研究旨在确定CBP的结节病患者中,中轴型放射学和非放射学SpA的患病率,并评估患者特征与SpA的关联。

这项横断面研究纳入了64例诊断为结节病的CBP患者。主诉CBP的患者接受完整的脊柱MRIX线摄影。所有的炎性CBP患者均行补充骶髂关节MRI检查。中轴型SpA的诊断基于脊柱关节炎国际学会评估的分类标准。

64名伴CBP的结节病患者中(49名女性),29名有炎性疼痛;15/64名被诊断为SpA23.4[95CI13.7-35.6]),炎性背痛患者中14/29被诊断为SpA48.3[95CI29.5-67.5])。13名患者发现有MRI骶髂关节炎。在单因素和多因素分析中,诊断为SpA与炎性CBPOR=28.595CI 1.91-425.4)和局限于胸部的结节病相关(OR=6.7495CI1.08-42.1)。仅在单因素分析中,SpA与年龄小(p=0.0093)和男性相关(p=0.021)。此外,12/64名患者(18.8%,95CI10.1-30.5)被诊断为结节病脊柱病变, 7/64名患者(10.9%,95CI4.5-21.2)有症状性椎体骨折,30/64名患者(46.9%,95CI34.3-59.8)有脊柱退行性变。

炎性背痛的结节病患者中SpA的患病率升高。在该亚组中系统地使用脊柱和骶髂MRI是合理的。其他患者特征与SpA间的关联需要进一步证实。

原始出处:

Johanna Sigaux. High prevalence of spondyloarthritis in sarcoidosis patients with chronic back pain. Semin Arthritis Rheu. 11 March 2019.

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    2019-03-16 lmm397
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    2019-03-16 zhaojie88

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