Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

Menolfi, D; Jiang, WX; Lee, BJ; Moiseeva, T; Shao, ZP; Estes, V; Frattini, MG; Bakkenist, CJ; Zha, S

Zha, S (reprint author), Columbia Univ, Coll Phys & Surg, Dept Pathol & Cell Biol, Inst Canc Genet, New York, NY 10032 USA.; Zha, S (reprint author), Columbia Univ, Dept Pediat, Coll Phys & Surg, Div Pediat Oncol Hematol & Stem Cell Transplantat, New York

NATURE COMMUNICATIONS, 2018; 9 ():

Abstract

ATR kinase is activated by RPA-coated single-stranded DNA (ssDNA) to orchestrate DNA damage responses. Here we show that ATR inhibition differs from A......

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