Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

Atkinson, SC; Dogovski, C; Wood, K; Griffin, MDW; Gorman, MA; Hor, L; Reboul, CF; Buckle, AM; Wuttke, J; Parker, MW; Dobson, RC; Perugini, MA

Perugini, MA (reprint author), Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, 30 Flemington Rd, Parkville, Vic 3010, Australia.; Perugini, MA (reprint author), La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Melbourn

STRUCTURE, 2018; 26 (7): 948

Abstract

Protein dynamics manifested through structural flexibility play a central role in the function of biological molecules. Here we explore the substrate-......

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