IRAP(+) endosomes restrict TLR9 activation and signaling

Babdor, J; Descamps, D; Adiko, AC; Tohme, M; Maschalidi, S; Evnouchidou, I; Vasconcellos, LR; De Luca, M; Mauvais, FX; Garfa-Traore, M; Brinkmann, MM; Chignard, M; Manoury, B; Saveanu, L

Manoury, B (reprint author), INSERM, Unite 1151, Paris, France.; Manoury, B (reprint author), CNRS, Unite 8253, Paris, France.; Manoury, B (reprint author), Univ Paris 05, Sorbonne Paris Cite, Fac Med Paris Descartes, Paris, France.; Saveanu, L (reprint a

NATURE IMMUNOLOGY, 2017; 18 (5): 509

Abstract

The retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum prevents their activation under basal conditions. TLR9 is activ......

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