Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1-mediated PTEN hypermethylation in HSC activation and proliferation

Zhu, H; He, CS; Zhao, HZ; Jiang, WJ; Xu, SB; Li, J; Ma, TT; Huang, C

Ma, TT; Huang, C (corresponding author), Anhui Med Univ, Anhui Prov Lab Inflammatory & Immun Dis, Anhui Inst Innovat Drugs, Sch Pharm, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.

FASEB JOURNAL, 2020; 34 (11): 14558

Abstract

Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10 (PTEN......

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