Diverse human V-H antibody fragments with bio-therapeutic properties from the Crescendo Mouse

Teng, YM; Young, JL; Edwards, B; Hayes, P; Thompson, L; Johnston, C; Edwards, C; Sanders, Y; Writer, M; Pinto, D; Zhang, YJ; Roode, M; Chovanec, P; Matheson, L; Corcoran, AE; Fernandez, A; Montoliu, L; Rossi, B; Tosato, V; Gjuracic, K; Nikitin, D; Bruschi, C; McGuinness, B; Sandal, T; Romanos, M

Teng, YM (corresponding author), Crescendo Biol Ltd, Babraham Res Campus, Cambridge CB22 3AT, England.

NEW BIOTECHNOLOGY, 2020; 55 (): 65

Abstract

We describe the `Crescendo Mouse', a human VH transgenic platform combining an engineered heavy chain locus with diverse human heavy chain V, D and J ......

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