Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis

Meng, HY; Liu, Z; Li, XY; Wang, HB; Jin, TJ; Wu, GW; Shan, B; Christofferson, DE; Qi, CT; Yu, Q; Li, Y; Yuan, JY

Li, Y; Yuan, JY (reprint author), Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai 201203, Peoples R China.; Yuan, JY (reprint author), Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (9): E2001

Abstract

RIPK1 is a critical mediator of cell death and inflammation downstream of TNFR1 upon stimulation by TNF alpha, a potent proinflammatory cytokine invol......

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