LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

Barth, J; Abou-El-Ardat, K; Dalic, D; Kurrle, N; Maier, AM; Mohr, S; Schutte, J; Vassen, L; Greve, G; Schulz-Fincke, J; Schmitt, M; Tosic, M; Metzger, E; Bug, G; Khandanpour, C; Wagner, SA; Lubbert, M; Jung, M; Serve, H; Schule, R; Berg, T

Berg, T (reprint author), Goethe Univ, Dept Med Hematol Oncol 2, Frankfurt, Germany.; Berg, T (reprint author), German Canc Consortium DKTK, Frankfurt, Germany.; Berg, T (reprint author), German Canc Res Ctr, Heidelberg, Germany.

LEUKEMIA, 2019; 33 (6): 1411

Abstract

LSD1 has emerged as a promising epigenetic target in the treatment of acute myeloid leukemia (AML). We used two murine AML models based on retroviral ......

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