Practical information on hemodialysis, hemofiltration, peritoneal dialysis and plasma filtration is featured in this journal. Recognizing the critical importance of equipment and procedures, particular emphasis has been placed on reports, drawn from a wide range of fields, describing technical advances and improvements in methodology. Papers reflect the search for cost-effective solutions which increase not only patient survival but also comfort through prevention or correction of undesirable effects. Advances in vascular access and blood anticoagulation as well as problems associated with exposure of blood to foreign surfaces also receive attention. Nephrologists, internists and hospital staff involved in dialysis, apheresis and immunoadsorption for acute and chronic solid organ failure will find this journal useful and informative.