The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms and comparative functional genomics; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; appetite and obesity, complex function of the central nervous system, sleep and locomotion; and inflammation and cytokines and temperature regulation. The editors wish to attract papers from physiologists who are united by broad interests in regulation, integration, and homeostasis in health and in disease.