投稿信息
稿件收录要求
· As lncRNAs and miRNAs have multiple targets, claims of their function mediated by a single target or pathway will not be accepted, unless multiple additional targets are investigated to support functional specificity. · The rationale to investigate a specific lncRNA or miRNA needs to be specified upfront in the introduction and justified in the context of other miRNAs known to be functional in that specific field. · The proposed function of the lnc-RNA or miRNA should be validated by gain and loss of function studies. · Primary cells should be used whenever possible to confirm findings in cell lines. · In depth investigation in the signaling pathway(s) regulated by the RNA species should be conducted. · Insight into the regulation of the RNA species and how it relates to the pathologic state should be provided. · If applicable: Details of initial screen used to identify RNA species involvement in pathway/disease (number of subjects, statistical tests employed, percent change from controls).