The aim of the American Journal of Transplantation is the rapid publication of new high quality data in organ and tissue transplantation and the related sciences. The journal will publish original articles, case reports, invited reviews, and letters to the editor. The journal will reflect the field and be an agent for advancing the field through critical reviews and news features, and consensus documents and guidelines. The journal will be directed at scientists and clinicians in transplantation but also at those in other fields who wish to follow transplantation. The scope is the international discipline of transplantation. This includes organ and tissue donation and preservation; tissue injury, repair, inflammation, and aging; immune recognition, regulation, effector mechanisms, and opportunities for induction of tolerance; histocompatibility; drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses; transplant complications; xenotransplantation; and ethical and societal issues. The sciences will include relevant aspects of cell biology, medicine, surgery, pediatrics, and infectious diseases. The journal will include thoracic transplantation (heart, lung), abdominal transplantation (kidney, liver, pancreas, islets), transplantation of tissues and related topics, and stem cell transplantation. AJT will serve as a forum for debate and reassessment, an agent of change, and a major new platform for promoting understanding, improving results, and advancing science in this dynamic field.