JAMA Pediatr:青少年阿片类处方模式与用药过量风险

2019-12-27 MedSci MedSci原创

研究结果表明,当向青少年提供处方类阿片药物时,医生应减少每日剂量,避免同时使用阿片和苯二氮卓类处方药,并尽量提供短效类阿片药物来减少过量使用风险

严控阿片处方对减少阿片滥用风险至关重要,然而先前的研究对象主要集中于老年人,近日研究人员考察了青少年阿片类药物滥用与处方模式的关系。

本次研究为回顾性队列研究,考察2009-17年间,12至21岁的私人保险,研究的主要终点为阿片类药物处方过量。

共有2752612名参与者,平均年龄17.2岁,女性占52.8%。,共有4686355例阿片类处方,相当于21605444人-天。249名患者中,255人-天出现过量用药(占样本的0.01%)。每日阿片类药物类别每增加一次都与更高的过量风险相关(校正比值比[AOR],1.18)。与没有使用相比,同时苯二氮卓使用(AOR:1.8)和缓释剂或长期阿片类药物的使用(AOR:2.01)与过量服用风险增加有关。

研究结果表明,当向青少年提供处方类阿片药物时,医生应减少每日剂量,避免同时使用阿片和苯二氮卓类处方药,并尽量提供短效类阿片药物来减少过量使用风险。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1639305, encodeId=69621639305ce, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed May 13 03:32:00 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728241, encodeId=59231e28241f7, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Jul 21 13:32:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309145, encodeId=830713091455e, content=<a href='/topic/show?id=a0179e879ac' target=_blank style='color:#2F92EE;'>#阿片类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97879, encryptionId=a0179e879ac, topicName=阿片类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Sun Dec 29 09:32:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035846, encodeId=43b010358468f, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Dec 27 21:32:00 CST 2019, time=2019-12-27, status=1, ipAttribution=)]
    2020-07-21 feather89
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    2019-12-29 lhlxtx
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    2019-12-27 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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