JACC:透析患者心脏结构异常,右心室收缩功能不全独立预测死亡

2016-03-09 MedSci MedSci原创

血液透析(HD)患者的心血管疾病与不良预后相关。急性透析质量倡议工作组提出了超声心动图(ECHO)在透析患者中的心脏结构异常(SHD)标准。SHD与重要的患者的预后的关联并不明确。这项研究旨在确定ECHO-确定的SHD患病率及其与HD幸存者之间的生存关联。研究人员分析了从2001年至2013年开始患有慢性HD之前≤1或HD后≤3个月接受ECHO(n=654)的患者。患者的平均年龄为66±16岁,6

血液透析(HD)患者的心血管疾病与不良预后相关。急性透析质量倡议工作组提出了超声心动图(ECHO)在透析患者中的心脏结构异常(SHD)标准。SHD与重要的患者的预后的关联并不明确。

这项研究旨在确定ECHO-确定的SHD患病率及其与HD幸存者之间的生存关联。

研究人员分析了从2001年至2013年开始患有慢性HD之前≤1或HD后≤3个月接受ECHO(n=654)的患者。

患者的平均年龄为66±16岁,60%的患者为男性。ECHO发现能够满足1条以上或≥3条的新标准的患者分别为87%和54%。在平均2.4年中,415例患者死亡:108例患者(26%)在6个月内死亡。五年的死亡率为62%。和死亡相关的年龄和性别调整的结构心脏疾病变量包括左室射血分数(LVEF)≤45%(危险比[HR]:1.48;置信区间(CI):1.20〜1.83)和右心室(RV)收缩功能障碍(HR:1.68; CI:1.352.07)。导致高死亡的危险性的因素包括LVEF≤45%和RV收缩功能障碍(HR:2.04; CI:1.57〜2.67;;相互作用检验P=0.53)。继调整了年龄,性别,种族,糖尿病肾病,透析,RV功能不全与死亡独立相关(HR:1.66; CI 1.34至2.06; P<0.001)。

在HD研究人群中SHD是常见的,RV收缩功能不全能够独立预测死亡率。

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    2016-09-07 hbwxf
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    2016-03-22 1de304d2m86(暂无匿称)

    值得学习

    0

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