FDA批准BRAF激酶抑制剂药物CEP-32496的临床试验申请

2012-05-24 jewell 生物谷

安比特生物科学（Ambit）和梯瓦药业（Teva）日前宣布FDA已批准其抗肿瘤药物CEP-32496的临床试验申请，此药属新型BRAF（V600E）激酶抑制剂。临床前研究证明CEP-32496在黑素瘤和结肠癌异种移植模型中具持续有效的抗肿瘤活性。 CEP-32496经口服后有较好的的药代动力学性质，公司表示，与其他BRAF（V600E）激酶抑制剂类药物（如索拉非尼（sorafenib）和RA

安比特生物科学（Ambit）和梯瓦药业（Teva）日前宣布FDA已批准其抗肿瘤药物CEP-32496的临床试验申请，此药属新型BRAF（V600E）激酶抑制剂。

临床前研究证明CEP-32496在黑素瘤和结肠癌异种移植模型中具持续有效的抗肿瘤活性。

CEP-32496经口服后有较好的的药代动力学性质，公司表示，与其他BRAF（V600E）激酶抑制剂类药物（如索拉非尼（sorafenib）和RAF-265）相比，CEP-32496抗癌疗效更佳。

Teva肿瘤与炎症研发部高级主管布鲁斯-鲁杰里（Bruce Ruggeri）称，“我们希望能充分发掘此候选药物的潜力，以改善BRAF（V600E）基因突变型肿瘤患者的症状。”（生物谷Bioon.com）

编译自Ambit, Teva announce FDA clearance of CEP-32496

>>相关阅读

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制药物 href="http://www.bioon.com/biology/bioenginering/436988.shtml">Nature：“模拟两可”的RAF抑制药物

FDA批准sorafenib治疗肾细胞癌

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2012-10-01 jklm09

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2013-02-24 smartjoy

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2012-06-18 ms8543593053280928

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2012-09-24 bugit

#FDA批准#

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2012-05-26 zhaojie88

#BRAF#

33 0
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2012-05-26 redcrab

#激酶#

26 0

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