The FASEB Journal:锻炼有助于老年人受损肌肉组织修复

2016-06-20 MedSci MedSci原创

麦克马斯特大学的人体运动学副教授Gianni Parise博士和同事联合进行这项研究,研究结果指出,运动可使老年人受损的肌肉组织重新生长。 许多哺乳动物包括人类和老鼠,随着年龄的增长,肌肉修复的速度逐渐减慢。事实上有一段时间内人们认为到达一定的年龄后骨骼肌无法完全修复。 麻省理工学院的Parise教授和同事们发现,实验组小鼠经过8周的锻炼后肌肉组织的修复速度远快于同年龄段、不运动的对照组小鼠。 他

麦克马斯特大学的人体运动学副教授Gianni Parise博士和同事联合进行这项研究,研究结果指出,运动可使老年人受损的肌肉组织重新生长。 


许多哺乳动物包括人类和老鼠,随着年龄的增长,肌肉修复的速度逐渐减慢。事实上有一段时间内人们认为到达一定的年龄后骨骼肌无法完全修复。
 
麻省理工学院的Parise教授和同事们发现,实验组小鼠经过8周的锻炼后肌肉组织的修复速度远快于同年龄段、不运动的对照组小鼠。 他们认为这一发现很重要,因为该发现表明锻炼对修复哺乳动物的肌肉组织有效。 

在他们的研究中,研究人员使用三组老鼠进行实验。实验组的年迈小鼠接受了为期8周的锻炼运动。第二组小鼠的年龄同实验组小鼠一致,但并不进行运动练习,第三组小鼠由年幼小鼠组成且不进行运动。 

在实验期间,研究人员将毒蛇体液注入小鼠腿部肌肉中(胫骨前肌)造成小鼠的肌肉损伤。研究人员于实验10天、28天后评估小鼠肌肉组织的恢复情况。结果显示,10天后,三组小鼠肌肉纤维横截面的平均面积减少,但是,到了第28天,只有实验组和第三组小鼠的肌肉组织得以恢复。研究人员认为,运动可修复小鼠受损的骨骼肌,并促进其再生。

成人成肌祖细胞平时处于静止状态,若机体出现损伤则会变得活跃。在受到刺激时,它们可修复受损肌肉组织并增加干细胞数量。研究人员发现,受伤前实验组小鼠成肌祖细胞数量多于第二组小鼠。Thoru Pederson博士指出,这项研究指出即使年龄较大的哺乳动物进行运动也可增加机体成肌祖细胞。他指出,尽管随着年龄的增加,肌肉组织收缩的能力下降,但是成肌祖细胞可减缓这种肌肉收缩力下降的程度。 

原始出处:

[1]Regular exercise may help muscle repair in older adults. MNT.2016 June 20.

[2]Sophie Joanisse, et al. Exercise conditioning in old mice improves skeletal muscle regeneration. The FASEB Journal. 2016 June 15.

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    2016-06-24 gracezdd
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    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

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    2016-09-16 ylzr123

    好文,值得学习,赞!

    0

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    2016-09-10 1e10c84am36(暂无匿称)

    好文章,百姓也能从中学到好多医学知识

    0

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    2016-08-30 ylzr123

    好文,值得学习,赞!

    0

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