Stroke:颅内动脉狭窄患者支架术后发生亚急性血栓的危险因素

2017-02-02 MedSci MedSci原创

近期,一项发表在杂志Stroke上的研究旨在探讨有症状的颅内动脉狭窄患者进行颅内支架术后的亚急性血栓形成(SAT)的危险因素。研究时间自2013年1月至2013年12月,收集北京天坛医院接受颅内支架置入的所有症状性颅内动脉狭窄患者并进行了前瞻性研究。发生SAT的患者的基线临床特征和手术数据与未发生SAT的患者进行比较。使用二元逻辑回归模型来确定与SAT相关的风险因素。此项研究结果显示:在入组的22

近期,一项发表在杂志Stroke上的研究旨在探讨有症状的颅内动脉狭窄患者进行颅内支架术后的亚急性血栓形成(SAT)的危险因素。


研究时间自2013年1月至2013年12月,收集北京天坛医院接受颅内支架置入的所有症状性颅内动脉狭窄患者并进行了前瞻性研究。发生SAT的患者的基线临床特征和手术数据与未发生SAT的患者进行比较。使用二元逻辑回归模型来确定与SAT相关的风险因素。

此项研究结果显示:在入组的221例患者中,9例(4.1%)患者在支架术后2〜8天发生SAT。二元Logistic分析显示SAT与串联支架术(OR,11.278;95%置信区间[CI],2.422-52.519)和抗血小板抵抗(阿司匹林抵抗:OR,6.267;95%CI,1.574-24.952;氯吡格雷抵抗:OR,15.526;95%CI,3.105-77.626;阿司匹林和氯吡格雷抵抗:OR,12.246;95%CI,2.932-51.147;以及阿司匹林或氯吡格雷抵抗:OR,11.340;95%CI,2.282-56.344)相关。

此项研究结果表明:串联支架置入和抗血小板抵抗可能有助于有症状的颅内动脉狭窄患者在颅内支架术后发生SAT。

原始出处:

Sun X, Tong X, Lo WT, et al. Risk Factors of Subacute Thrombosis After Intracranial Stenting for Symptomatic Intracranial Arterial Stenosis. Stroke. 2017 Jan 27. pii: STROKEAHA.116.015538.

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    2017-06-02 gujh
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    2017-10-13 qindq
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    2017-02-18 虈亣靌

    好东西大家一起学!

    0

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    2017-02-03 卡圣

    长见识了

    0

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    2017-02-03 susice

    这么说术前查血栓弹力图和波立维基因是有必要的咯

    0

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