Hepatology:非酒精性脂肪肝患者可能导致心衰风险

2015-08-21 徐媛媛 MedSci原创

非酒精性脂肪肝(NAFLD)和心力衰竭(HF)导致高心血管死亡率。非酒精性脂肪肝(NAFLD)与亚临床心肌重构及功能障碍是否相关,目前尚未知晓。 研究人员对2713名CARDIA患者进行横断面多中心分析。所收纳的患者中有8.8%为女性,48%为黑人,NAFLD患病率为10%(n=271)。研究人员通过计算机断层扫描(CT)进行肝部脂肪量化,通过超声斑点追踪成像技术测定心肌



非酒精性脂肪肝(NAFLD)和心力衰竭(HF)导致高心血管死亡率。非酒精性脂肪肝(NAFLD)与亚临床心肌重构及功能障碍是否相关,目前尚未知晓。

研究人员对2713名CARDIA患者进行横断面多中心分析。所收纳的患者中有8.8%为女性,48%为黑人,NAFLD患病率为10%(n=271)。研究人员通过计算机断层扫描(CT)进行肝部脂肪量化,通过超声斑点追踪成像技术测定心肌张力。使用左室整体纵向应变(GLS)绝对峰值对亚临床左室收缩功能障碍进行定义。
研究结果显示,与无NAFLD的患者相比,NAFLD患者的舒张早期充盈速率较低(10.8±2.6 vs.11.9±2.8 cm/s),且左室充盈压较高(E/e':7.7 ± 2.6 vs. 7 ± 2.3),绝对GLS较差(14.2 ± 2.4% vs. 15.2 ± 2.4%,P值均 < .0001)。NAFLD患者心输出量更高,校正人体表面积之后有所减弱。经校正,NAFLD心衰风险因素或BMI后仍与亚临床心肌重构及功能障碍有关(P < 0.01),表明诊断NAFLD可能有助识别心衰发病风险升高的个体。

非酒精性脂肪肝(NAFLD)与亚临床心肌重构及功能障碍独立相关,而且可能与心衰有关。

原始出处

VanWagner LB1,2, Wilcox JE1,3, Colangelo LA1, Lloyd-Jones DM1,3, Carr JJ4, Lima JA5, Lewis CE6, Rinella ME2, Shah SJ3.Association of nonalcoholic fatty liver disease with subclinical myocardial remodeling and dysfunction: A population-based study.Hepatology. 2015 Apr 24

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    2015-08-23 gwc384

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