Cancer Res:较高的BMI和 2型糖尿病均可增加肝癌的发病风险

2016-10-16 MedSci MedSci原创

近期发表于Cancer Research的一项大规模的研究发现,较大的身体质量指数、腰围增加及 2型糖尿病与肝癌的发病风险增加有关。研究人员来自美国国家癌症研究所的研究人员,收集了参与美国14个独立研究的157万名参与者的数据。每一个研究中,收集与体重、腰围、身高、烟草使用,酒精摄入量和其他癌症相关风险的问卷调查数据。总体而言,6.5%的研究对象发生了2型糖尿病,2162名发生了肝癌。分析数据发现

近期发表于Cancer Research的一项大规模的研究发现,较大的身体质量指数、腰围增加及 2型糖尿病与肝癌的发病风险增加有关。

研究人员来自美国国家癌症研究所的研究人员,收集了参与美国14个独立研究的157万名参与者的数据。每一个研究中,收集与体重、腰围、身高、烟草使用,酒精摄入量和其他癌症相关风险的问卷调查数据。

总体而言,6.5%的研究对象发生了2型糖尿病,2162名发生了肝癌。

分析数据发现,身体质量指数(BMI)每增加5公斤/平方米,肝癌的发生风险相应增加;在男性中相当于增加38%,女性中增加25%。

至于腰围,腰围每增加5公分,肝癌的发生风险增加8%。

校正吸烟、种族、饮酒和BMI后,2型糖尿病患者发生肝癌的几率为非2型糖尿病者的2.61倍;这一风险增加与BMI的增加是一致的。

结果显示,体重指数、腰围和2型糖尿病这三个因素都会增加肝癌的发生风险。

已知肥胖相关的癌症包括大肠癌、绝经后乳腺癌、肾癌、子宫内膜癌、甲状腺癌和胆囊癌。而本研究又发现肝癌也与肥胖相关。

虽然这项研究并不能证明肝癌发生风险的增加仅仅是因为肥胖,但它表明,该风险的增加有肥胖的因素。不应再将肝癌的病因局限于酒精滥用和肝炎。

原始出处:

Tim Newman. High BMI and type 2 diabetes linked to liver cancer. MNT, 14 October 2016.

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    2016-10-19 1e0ece0dm09(暂无匿称)

    谢谢指点学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=149619, encodeId=e97c1496191d, content=谢谢指点学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 19 00:42:22 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149426, encodeId=f89c14942644, content=嗯!很好的文献, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue Oct 18 09:03:56 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149393, encodeId=26ad149393e7, content=继续关注,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Oct 18 07:52:56 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148939, encodeId=352f14893958, content=嗯,很好的文章,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Mon Oct 17 08:38:06 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148907, encodeId=359f14890eb2, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Oct 17 06:49:13 CST 2016, time=2016-10-17, status=1, ipAttribution=)]
    2016-10-18 cqykthl

    嗯!很好的文献

    0

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    2016-10-18 童小孩

    继续关注,学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=149619, encodeId=e97c1496191d, content=谢谢指点学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 19 00:42:22 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149426, encodeId=f89c14942644, content=嗯!很好的文献, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue Oct 18 09:03:56 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149393, encodeId=26ad149393e7, content=继续关注,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Oct 18 07:52:56 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148939, encodeId=352f14893958, content=嗯,很好的文章,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Mon Oct 17 08:38:06 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148907, encodeId=359f14890eb2, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Oct 17 06:49:13 CST 2016, time=2016-10-17, status=1, ipAttribution=)]
    2016-10-17 蓬莱阁

    嗯,很好的文章,谢谢

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=149619, encodeId=e97c1496191d, content=谢谢指点学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 19 00:42:22 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149426, encodeId=f89c14942644, content=嗯!很好的文献, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue Oct 18 09:03:56 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149393, encodeId=26ad149393e7, content=继续关注,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Tue Oct 18 07:52:56 CST 2016, time=2016-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148939, encodeId=352f14893958, content=嗯,很好的文章,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2291960840, createdName=蓬莱阁, createdTime=Mon Oct 17 08:38:06 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148907, encodeId=359f14890eb2, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Oct 17 06:49:13 CST 2016, time=2016-10-17, status=1, ipAttribution=)]
    2016-10-17 忠诚向上

    好好学习

    0

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研究显示,民众肥胖或超重的时间越久,患癌的风险就越高。研究发表在PLoS Medicine。Melina Arnold博士指出,本研究是第一项评估绝经后妇女超重和肥胖的持续时间对她们患癌风险影响的研究。 Arnold博士和同事发现,成人超重的持续时间每增加10年,则患癌风险增加7%。其中患子宫内膜癌的风险最高(17%),其次是肾癌(16%), 患乳腺癌的风险增加5%,但研究人员未发现肥胖和超重的持