Cerebrovasc Dis:脑出血中的淀粉样血管病

2018-04-18 国际循环编辑部 国际循环

脑出血(ICH)的危险因素包括高血压和脑淀粉样血管病(CAA)。近日,巴黎狄德罗大学Guidoux C等发表于Cerebrovascular Diseases杂志的一项研究旨在探讨确定ICH死亡患者中CAA发病率,CAA与其他危险因素的可能潜在重叠因素,以及CAA与脑微出血灶的相关性。

脑出血(ICH)的危险因素包括高血压和脑淀粉样血管病(CAA)。近日,巴黎狄德罗大学Guidoux C等发表于Cerebrovascular Diseases杂志的一项研究旨在探讨确定ICH死亡患者中CAA发病率,CAA与其他危险因素的可能潜在重叠因素,以及CAA与脑微出血灶的相关性。

研究者分析了ICH患者的81个连续尸检大脑。染色进行CAA检测,使用年龄和性别匹配的非神经系统病变患者正常脑解剖作为对照组来确定CAA和高血压发病率。对ICH的11个尸检脑组织进行3D磁共振(MRI)梯度回波T2加权成像(1.5 T磁体)(5例为CAA),并对检测的微出血灶进行组织学检测。

结果发现,高血压和CAA发生率分别为69.1%和24.7%。在CAA患者中,65.0%也有高血压。非高血压患者和对照组的CAA患病率相似(33.3%和23.1%;P=0.54),而高血压患者与对照组具有明显差异(28.9% vs. 0;P=0.01)。MRI记录了48个微出血,5例CAA患者有≥1微出血。在MRI的48个微出血中,组织学检测发现45个为微血管周围的出血(23个出血直径<200 µm,19个为200 µm~2 mm之间,3个为含铁血黄素颗粒)。

研究表明,高血压与CAA在ICH患者中经常并存。通过组织学分析证实,MRI检测的微出血CAA患者是高血压ICH患者的两倍。

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    2019-01-06 quxin068
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    2018-04-19 张新亮1853311252142e2fm

    好文献.学习了

    0

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    2018-04-19 changjiu

    学习一下谢谢

    0

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    2018-04-18 wqkm

    ^_^^_^^_^^_^

    0

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    2018-04-18 戒馋,懒,贪

    谢谢分享学习了

    0

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