Diabetes Care:外周血干细胞可预测2型糖尿病患者心血管疾病长期预后

2016-11-07 xing.T MedSci原创

由此可见,2型糖尿病患者循环中CD34+干细胞基础水平降低,可以预测6年后不良心血管事件的预后,并改善心血管疾病危险分层。

糖尿病患者心血管疾病的风险存在很大的变异性,生物标志物可以改善糖尿病患者心血管疾病的风险分层。有研究表明外周血干细胞可以预测心血管事件和死亡情况,但在糖尿病患者中此项数据是很少的。近日,糖尿病领域权威杂志Diabetes Care发表了一篇研究文章,在这项研究中,研究人员评估了外周血干细胞水平预测心血管疾病预后和改善2型糖尿病患者心血管疾病危险分层的能力。

研究者对187例2型糖尿病患者进行了6.1年的随访,主要结局事件是第一次发生心血管事件的时间,该指标中的心血管事件具体可以定义为3种主要的不良心血管事件(心血管死亡、非致死性心肌梗死或非致死性卒中)和因心血管疾病导致的住院。在研究之初,研究人员测量了外周血里表达CD34、CD133和KDR的六种表型的干/祖细胞的水平。

48例(4.5/100例病人/年)糖尿病患者发生主要结局事件,相比于没有CD34+细胞和CD34+/CD133+细胞的糖尿病患者,含有CD34+细胞和CD34+/CD133+细胞的糖尿病患者心血管事件的发生率显著降低。在含有CD34+细胞和CD34+/CD133+细胞水平位于中位水平以下的糖尿病患者,其心血管事件发生率较高。研究者通过Cox比例风险回归分析发现,降低的CD34+细胞(风险比为2.21,95%可信区间为1.14–4.29)和CD34+/CD133+细胞(风险比为2.98,95%可信区间为1.46–6.08)计数可以独立预测心血管事件的发生。

由此可见,2型糖尿病患者循环中CD34+干细胞基础水平降低,可以预测6年后不良心血管事件的预后,并改善心血管疾病危险分层。

原始出处:

Gian Paolo Fadini,et al. Long-term Prediction of Cardiovascular Outcomes by Circulating CD34+ and CD34+CD133+ Stem Cells in Patients With Type 2 Diabetes. Diabetes Care. 2016 Nov; dc161755. http://dx.doi.org/10.2337/dc16-1755

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  5. 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objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498086, encodeId=8f30149808624, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578521, encodeId=96c115e85213e, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
    2016-11-10 laoli

    谢谢分享!学习了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1901495, encodeId=a7ed1901495b5, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Feb 27 13:34:00 CST 2017, time=2017-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645562, encodeId=a7f91645562ae, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498086, encodeId=8f30149808624, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578521, encodeId=96c115e85213e, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Nov 09 00:34:00 CST 2016, time=2016-11-09, status=1, ipAttribution=)]
    2016-11-10 1dedfe95m66(暂无匿称)

    又是CD34+

    0

  7. 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