Science子刊：一类降糖药物虽不增加肿瘤风险，但促进肿瘤转移

2016-04-17 MedSci MedSci原创

中国研究人员一项新研究显示，糖尿病药物中的抗氧化剂有可能会促使肿瘤扩散，这提示医生不要给同时罹患糖尿病与肿瘤的患者滥用抗氧化剂。这项研究4月13日发表在新一期美国《科学转化医学》杂志上，两名研究负责人是第三军医大学新桥医院内分泌科主任郑宏庭和第三军医大学西南医院副主任医师余时沧。他们介绍说，大量证据表明糖尿病增加多种肿瘤的发生风险，因此糖尿病合并肿瘤患者日益增多。这些患者也需采取降

中国研究人员一项新研究显示，糖尿病药物中的抗氧化剂有可能会促使肿瘤扩散，这提示医生不要给同时罹患糖尿病与肿瘤的患者滥用抗氧化剂。

这项研究4月13日发表在新一期美国《科学转化医学》杂志上，两名研究负责人是第三军医大学新桥医院内分泌科主任郑宏庭和第三军医大学西南医院副主任医师余时沧。

他们介绍说，大量证据表明糖尿病增加多种肿瘤的发生风险，因此糖尿病合并肿瘤患者日益增多。这些患者也需采取降糖治疗，然而降糖治疗有可能通过多种途径对肿瘤的生物学行为产生潜在影响。因此，科学评价这种影响，对糖尿病合并肿瘤患者的合理用药具有重要意义。

小鼠实验发现，目前广泛应用的降糖药物---DDP4抑制剂saxagliptin 和sitagliptin，也作为一种ALA，虽然不增加肿瘤发生，但却可以促进肿瘤转移。降糖药物中的一些抗氧化剂虽然不会诱导新生肿瘤的发生，但会增加已有肿瘤转移的风险，其中包括结肠癌和肝癌。这提示糖尿病合并肿瘤患者在使用这些药物时需谨慎评估。

进一步研究揭示了这种现象的发生机制，即这些降糖药物是通过激活抗氧化信号通路NRF2，促进肿瘤转移与侵袭。氧自由基在肿瘤中是双面角色（Cancer Cell：与恶魔共舞的活性氧自由基）

《科学转化医学》杂志此前刊登的另一项研究也显示，包括维生素E在内的抗氧化剂会增加烟民等高危人群患肺癌的风险（STM：吸烟者服用维生素增加患癌风险）。

此前也有类似研究，如：Nature：再证明食用抗氧化剂会促进癌症转移； Sci Transl Med：抗氧化剂可加快肿瘤细胞转移速度；NEJM：抗氧化剂如何加速癌症发生；Science：抗氧化剂可能会通过作用于癌症基因的方式诱发癌症，这些研究支持抗氧化剂促进肿瘤转移。

当然，大部分研究认为抗氧化剂可以减少肿瘤的发生，如Science：震惊！300个橙子产生的维生素C，可以破坏癌细胞！

原始出处：

Wang H, Liu X, Long M, Huang Y, Zhang L, Zhang R, Zheng Y, Liao X, Wang Y, Liao Q, Li W, Tang Z, Tong Q, Wang X, Fang F, de la Vega MR, Ouyang Q, Zhang DD, Yu S, Zheng H. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis. Sci Transl Med. 2016 Apr 13;8(334):334ra51

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2016-09-21 mjldent

#肿瘤风险#

53 0
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2016-04-25 1dea6088m20(暂无匿称)

抗氧化剂通常是防肿瘤发生相关的，抗氧化剂有使肿瘤扩散的机制研究结论哪些

115 0
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2016-04-19 李继凯

文章高大上

123 0
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2016-04-19 一叶知秋

#降糖药#

36 0
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2016-04-19 docwu2019

#肿瘤转移#

36 0
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2016-04-19 jichang

#SCIE#

33 0
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2016-04-19 yuhaisheng_ibp_32061711

#降糖药物#

37 0
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2016-04-17 dhzzm

对肿瘤患者应该慎用

101 0

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