JAHA:冠状动脉疾病与射血分数正常的心衰的关系

2022-08-27 MedSci原创 MedSci原创

在对人口统计资料和常见合并征进行调整后,冠心病是HFpEF发生的一个重要危险因素。

射血分数正常的心衰(HFpEF)是一个主要的公共卫生问题,其患病率随着人口老龄化而上升。冠状动脉疾病(CAD)是否为射血分数正常的心衰(HFpEF)患者重要危险因素尚未明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,在9902名参与社区动脉粥样硬化风险(ARIC)研究的参与者中,研究人员评估了冠心病与随后发生的HFpEF(左心室射血分数≥50%)和HFrEF(左心室射血分数<50%),研究人员使用具有时间更新变量的生存模型。研究人员还评估了超声心动图在冠心病和HFpEF发病之间的相关性。

在13年的随访中,892名参与者发生冠心病,178人随后发生HF(86人为HFrEF,71人为HFpEF)。冠心病事件发生早期HFrEF和HFpEF发生风险均最大。在CAD事件发生1年以后,调整后的HFrEF和HFpEF发生率相似(每1000人年分别为7.2[95%CI为5.2-10.0]和6.7[4.8-9.2]),且CAD对两者仍具有预测性(HFrEF:风险比为2.76[95%CI为1.99-3.84];HFpEF:风险比为1.85[1.35-2.54])。

在第5次随访(2011-2013)的4779名无HF患者中,490名冠心病患者的左室射血分数较低,左室质量指数、E/E′和左房容积指数较高(均P<0.01)。经过超声心动图测量调整后,CAD患病率与随访5后HFpEF发生率的相关性并不显著,左室舒张功能衰减最大。

由此可见,在对人口统计资料和常见合并征进行调整后,冠心病是HFpEF发生的一个重要危险因素。这种关系部分归因于超声心动图结果的改变,特别是左室舒张功能的改变。

原始出处:

Jenine E. John.et al.Coronary Artery Disease and Heart Failure With Preserved Ejection Fraction: The ARIC Study.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021660

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    2022-08-28 zhaohui6731
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