Diabetic Med:HbA 1c变异性与1型糖尿病患者的死亡率和早期住院率相关

2017-10-27 MedSci MedSci原创

尽管HbA 1c变异性与1型糖尿病发病率的证据,但是没有证据表明HbA 1c变异性与1型糖尿病死亡率之间存在关系。近日,国际杂志 《Diabetic Medicine》上在线发表一项关于HbA 1c变异性与1型糖尿病患者的死亡率和早期住院率相关的研究。研究人员进行了一项观察性研究,以调查1型糖尿病人群中HbA 1c变异性和死亡率之间的关联。作为次要结果,研究人员比较了组间首次入院的时间。

尽管HbA 1c变异性与1糖尿病发病率的证据,但是没有证据表明HbA 1c变异性与1糖尿病死亡率之间存在关系。近日,国际杂志 《Diabetic Medicine》上在线发表一项关于HbA 1c变异性与1糖尿病患者的死亡率和早期住院率相关的研究。研究人员进行了一项观察性研究,以调查1型糖尿病人群中HbA 1c变异性和死亡率之间的关联。作为次要结果,研究人员比较了组间首次入院的时间。

从苏格兰护理信息-糖尿病数据集中确定1型糖尿病患者。该数据库包括所有已知在苏格兰患有糖尿病的人的数据。比较两组47个月的生存分析; 1HbA 1c变异系数(CV)高于CV中位数值,组2CV低于中位数值。此外,还分析了死亡或首次入院的时间。使用Cox比例风险模型来比较死亡时间,校正协变量。

研究有60481型糖尿病患者被纳入分析。HbA 1c CV中位数为7.9。超过47个月的随访中,HbA 1c CV高于中位数值患者的死亡率风险比(HR)为1.5P <0.001)。在超过730天的随访中,HbA 1c CV高于中位数的患者首次入院或死亡的HR1.3595%置信区间1.25-1.45)(P  <0.001)。

研究结果表明,HbA 1c变异性较大,患者死亡率高,1型糖尿病早期住院率较高。

原始出处:

G. S. Walker, S. G. Cunningham, C. A. R. Sainsburyet al. You have free access to this contentHbA1c variability is associated with increased mortality and earlier hospital admission in people with Type 1 diabetes

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  6. 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  7. 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  8. 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encodeId=322a16081e727, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Oct 29 11:21:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256483, encodeId=80952564830a, content=非常好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Oct 27 23:10:06 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
  9. 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encodeId=322a16081e727, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Oct 29 11:21:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256483, encodeId=80952564830a, content=非常好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Oct 27 23:10:06 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-10-27 天涯183

    非常好的文章.谢谢

    0

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