Diabetes Obes Metab:伴有1型糖尿病和高血压儿童和青少年心血管危险因素患病率增加

2022-08-23 MedSci原创 MedSci原创

伴有高血压/血压升高的T1D青少年中可变CVRF的患病率高于正常血压的青少年,这表明他们在未来发病率和死亡率方面更易感,需要早期发现和干预。

伴有高血压和其他心血管危险因素(CVRFs)加速了1型糖尿病(T1D)从儿童时期开始的血管损伤。近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,该研究旨在调查了T1D患者中可变CVRFs的患病率,包括血脂异常、肥胖和高糖化血红蛋白(HbA1c),并评估了它们与血压类别之间的相关性。

研究人员分析了来自SWEET国际数据库的21634名T1D儿童和青少年,其中包括2010-2021年期间一年内3次以上随访测量得到诊室血压值。根据上一治疗年内的血压中位数,参与者被分为血压正常、血压升高(90-94个百分位)和高血压(≥95个百分位)。血脂异常(胆固醇≥200mg/dl和/或HDL-C≤40mg/dl和/或LDL-C≥100mg/dl)、肥胖(BMI≥2SDS)和HbA1c升高(≥9%)的患病率在每个血压类别中进行了评估。

与正常血压者相比,血压升高/高血压患者的血脂水平较差,肥胖患病率较高,糖化血红蛋白≥9%。此外,38.4%的高血压患者和36.0%的血压升高患者有1个CVRF,15.1%的高血压和10.1%血压升高患者有2个CVRF,2.3%和0.8%有3个CVRF。高血压/血压升高患者1个以上CVRFs的患病率高于血压正常者(p<0.001)。肥胖是与高血压相关的最强CVRF。女孩1个以上CVRF的患病率高于男孩。年龄≥13岁的高血压患者与年龄<13岁的高血压患者结果相似。

由此可见,伴有高血压/血压升高的T1D青少年中可变CVRF的患病率高于正常血压的青少年,这表明他们在未来发病率和死亡率方面更易感,需要早期发现和干预。
 
原始出处:
 
Andriani Vazeou,et al.Increased prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes and hypertension: The SWEET international database.Diabetes Obesity & Metabolism.2022.https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14834

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CST 2022, time=2022-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897060, encodeId=a2c2189e060c4, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Thu Dec 29 13:58:20 CST 2022, time=2022-12-29, status=1, ipAttribution=)]
    2022-08-26 docwu2019
  5. 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CST 2022, time=2022-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897060, encodeId=a2c2189e060c4, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Thu Dec 29 13:58:20 CST 2022, time=2022-12-29, status=1, ipAttribution=)]
    2023-06-28 guojianrong
  6. 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  7. 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    2022-12-29 一闲

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