每日病例丨肝病经典病例推荐-丙型肝炎

2017-11-10 MedSci MedSci原创

丙型病毒性肝炎主要经输血、针刺、吸毒等传播,据世界卫生组织统计,全球约1.8亿人感染了HCV,每年新发丙型肝炎病例约3.5万例。丙型肝炎呈全球性流行,可导致肝脏慢性炎症坏死和纤维化,部分患者可发展为肝硬化甚至肝细胞癌(HCC)。病史:患者15年前因车.导致脾脏破裂,行脾脏切除术,术中输血400 ml,否认烟酒等不良嗜好。3年前患者因常规体检发现丙氨酸氨基转移酶(ALT)105 IU/L。 在附近医



丙型病毒性肝炎主要经输血、针刺、吸毒等传播,据世界卫生组织统计,全球约1.8亿人感染了HCV,每年新发丙型肝炎病例约3.5万例。丙型肝炎呈全球性流行,可导致肝脏慢性炎症坏死和纤维化,部分患者可发展为肝硬化甚至肝细胞癌(HCC)。

病史:

患者15年前因车.导致脾脏破裂,行脾脏切除术,术中输血400 ml,否认烟酒等不良嗜好。

3年前患者因常规体检发现丙氨酸氨基转移酶(ALT)105 IU/L。 在附近医院就医,当时检查乙肝病毒标志物均阴性,未检测丙肝病毒标志物,服用当飞利肝宁、水飞蓟宾等保肝药物治疗3个月后ALT恢复正常,未正规随访。

2个月前因工作劳累、失眠后出现乏力、肝区不适及恶心等症状,来院就诊查肝功能,TB/DB 25.1/15.8(μmol/L) ,ALT/AST 312/197(IU/L) ,ALP?GGT 105/175(IU/L) ,凝血酶原时间为12.9s,丙肝病毒抗体:阳性,丙肝病毒载量:5.O*10^6 拷贝/m1。HCVRNA基因型为1b。发病至今患者无发热、腹痛及腹胀,未出出现皮肤发黄及尿色加深。

查体:

患者神志清楚,精神佳,肝病面容,全身皮肤.膜无黄染,未发.肝掌及蜘蛛痣,腹平软,无腹壁静脉曲张,肝肋下未及,未触及异常包块,双下肢无水肿。

辅助检查:

B超:肝区光点增强增粗提示慢性肝病,腹水(一)

肝穿刺病理:中度炎症伴纤.化G3S2。

血常规:白细胞WBC 6.35 *10^9/L、中性粒比率N 70 %、红细胞RBC 3.10 *10^12?L、血小板PLT 125 *10^9/L

大生化:TB/DB 20.8/16.0 μmol/L、A?G 40/28 g/L、ALT?AST 215/129 IU/L、ChE 8050 IU/L

凝血功能:PA 0.15 g?L、PT 12.6 s、INR 1.25

其他:HCV-RNA 4.0 *10^5拷贝/ml、HCV-Ab 阳性、乙肝病毒标志物阴性

简要解析:

此例患者有明确的外伤和输血史,丙肝病毒标志物阳性HCV-RNA 为4.0*10^5拷贝/ml,存在慢性肝脏损伤的生化改变;3、影像学检查及肝活检有慢性肝病的依据。故可明确诊断为丙肝。

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    2017-11-24 wqkm

    ^_^^_^^_^^_^^_^

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    2017-11-24 wqkm

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likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Nov 10 20:00:39 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2017-11-21 虈亣靌

    谢谢分享学习了

    0

  4. 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content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 11 08:34:20 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260425, encodeId=1b872604258b, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sat Nov 11 07:22:50 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260332, encodeId=8898260332b1, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Nov 10 20:00:39 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2017-11-19 wxl882001

    学习一下

    0

  5. 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content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 11 08:34:20 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260425, encodeId=1b872604258b, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sat Nov 11 07:22:50 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260332, encodeId=8898260332b1, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Nov 10 20:00:39 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2017-11-14 虈亣靌

    好好看下.内容丰富

    0

  6. 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likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Nov 10 20:00:39 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
  7. 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createdTime=Fri Nov 24 21:59:45 CST 2017, time=2017-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263115, encodeId=8ee2263115ae, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Nov 21 13:45:16 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262611, encodeId=3041262611b2, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Nov 19 17:09:26 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261288, encodeId=aa1f261288eb, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Nov 14 18:30:50 CST 2017, time=2017-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274606, encodeId=f94f12e460600, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, 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content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 11 08:34:20 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260425, encodeId=1b872604258b, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sat Nov 11 07:22:50 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260332, encodeId=8898260332b1, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Nov 10 20:00:39 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2017-11-11 人间可客

    学习了.谢谢分享!

    0

  8. 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likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Nov 10 20:00:39 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2017-11-11 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

  9. 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likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Nov 10 20:00:39 CST 2017, time=2017-11-10, status=1, ipAttribution=)]
    2017-11-11 雅文博武

    学习了很多先进的医疗技术

    0

  10. 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    2017-11-10 131****1460

    学习了受益匪浅

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