BMC Cancer：好消息！UPLC-MS血液脂类分析可早期诊断肝癌！

2015-12-21 Seven L 译 MedSci原创

慢性乙型病毒性肝炎 (CHB) 病毒感染是肝细胞性肝癌(HCC)的主要病因，若不能早诊断HCC，患者预后将会非常糟糕。目前临产上迫切需要能够对对于HCC做出早期精确诊断的生物标志物。研究者进行了一项研究，探究血液中有没有可以作为诊断乙肝相关HCC的潜在标志物。该研究纳入了32名HCC患者，30名肝硬化（LC）患者，25名CHB患者，还有34名健康人群。使用UPLC-MS分析参与者血液中脂类组学情况

慢性乙型病毒性肝炎 (CHB) 病毒感染是肝细胞性肝癌(HCC)的主要病因，若不能早诊断HCC，患者预后将会非常糟糕。目前临产上迫切需要能够对对于HCC做出早期精确诊断的生物标志物。研究者进行了一项研究，探究血液中有没有可以作为诊断乙肝相关HCC的潜在标志物。

该研究纳入了32名HCC患者，30名肝硬化（LC）患者，25名CHB患者，还有34名健康人群。使用UPLC-MS分析参与者血液中脂类组学情况。

研究数据显示，基于UPLC-MS检测血液中脂类，对于LC患者，该检测比常用的AFP在诊断LC上会更精确。该方法从LC患者中区分HCC患者的敏感性为78%，特异性是64%；而AFP的敏感性和特异性分别为38%和93%。使用UPLC-MS方法区分CHB和HCC的敏感性和特异性均为100%。

研究结果表明，对HCC高危人群进行基于UPLC-MS方式的血液脂类组学分析，可有效且方便的诊断HCC。

原始出处：

Passos-Castilho AM, Carvalho VM,et al.Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography-mass spectrometry.BMC Cancer. 2015 Dec 18;15(1):985.

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#插入话题

插入图片

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2016-10-20 ms3025846204744509

#BMC#

24 0
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2016-01-26 ssummer

需要看下原文

122 0
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2015-12-29 xyfg98

这个不错

96 0
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2015-12-27 wzf990214

赞

107 0
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2015-12-23 wzf990214

有意思！下载原文看看！

110 0
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2015-12-23 一叶知秋

#早期诊断#

27 0

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