Eur J Dent:他汀类药物或可改善高脂血症患者的牙周非手术治疗效果

2016-03-30 MedSci MedSci原创

本研究旨在探讨高血脂患者对牙周非手术治疗的反映效果,以及高血脂患者使用他汀类药物是否会影响牙周非手术治疗的疗效。

本研究旨在探讨高血脂患者对牙周非手术治疗的反映效果,以及高血脂患者使用他汀类药物是否会影响牙周非手术治疗的疗效。


研究共纳入了107名慢性牙周炎患者(35名血脂正常[NL],36名未接受药物治疗的高脂血症患者,36名接受他汀类药物治疗的高脂血症患者)。基线时期以及牙周非手术治疗后3个月评估所有研究对象的牙周参数(菌斑指数、牙龈指数[GI],探测深度[PD],临床附着水平[CAL])和生化指标(血浆甘油三酯[TG]、总胆固醇[TC]、低密度脂蛋白胆固醇[LDL-C]和高密度脂蛋白胆固醇[HDL-C])。

结果发现,与未接受药物治疗的高脂血症组患者相比,NL组和他汀类药物组患者的GI得到明显的改善。PD的平均变化与基线时期TC和LDL-C的水平呈负相关,而GI的平均变化则与基线时期HDL-C的水平呈正相关。回归分析显示,PD的平均变化与LDL-C呈负相关,而GI的平均变化与HDL-C呈正相关。

虽然基线时期较高的血脂水平不利于牙周治疗后的炎症消除情况,但是相比未接受他汀类药物治疗的患者,接受他汀类药物治疗的高脂血症患者似乎可改善牙周治疗的临床反应结果。该研究结果表明他汀类药物或可辅助牙周治疗,值得进一步研究。

原始出处:

Sangwan A, Tewari S, Singh H, Sharma RK, Narula SC. Effect of hyperlipidemia on response to nonsurgical periodontal therapy: Statin users versus nonusers. Eur J Dent. 2016 Jan-Mar;10(1):69-76. doi: 10.4103/1305-7456.175685.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 12 19:16:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044399, encodeId=568a20443993c, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Nov 26 16:48:00 CST 2016, time=2016-11-26, status=1, ipAttribution=), 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createdBy=73fb3217487, createdName=chentianping, createdTime=Fri Apr 01 12:48:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450463, encodeId=b7831450463eb, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Apr 01 12:48:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574559, encodeId=1c4115e4559f3, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Fri Apr 01 12:48:00 CST 2016, time=2016-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=75045, encodeId=3bc5e504592, content=期待进一步研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3a411691127, createdName=1de5aaa9m95(暂无匿称), createdTime=Thu Mar 31 18:49:00 CST 2016, time=2016-03-31, status=1, ipAttribution=)]
    2016-09-12 ylzr123

    赞,深度好文,学习。

    0

  5. 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  6. 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  7. 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  8. 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  9. 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    2016-04-01 pcw111
  10. 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    2016-03-31 1de5aaa9m95(暂无匿称)

    期待进一步研究

    0

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