JAHA:急性脑出血后心率变异性对结局的影响

2021-08-14 MedSci原创 MedSci原创

急性ICH初始24小时内平均HR和HR-ARV的增加与不良结局独立相关。此外,HR-ARV与24小时血肿扩大相关。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在探讨急性脑出血(ICH)后最初24小时内心率(HR)和心率变异性(HRV)的临床意义,以及如何导致更差的临床结局。

在ATACH-2(脑出血降压治疗2)试验中,在随机分组后的最初24小时内,从基线到1小时每15分钟和每小时记录一次HR。研究人员计算了以下内容:平均值、标准偏差、变异系数、连续变异和平均实际变异(ARV)。结局为24小时血肿扩大和不利的功能结局,定义为90天时改良Rankin量表评分为4至6。

在ATACH-2试验中的1000名受试者中,994名具有可用HR数据的受试者被纳入分析。总体而言,262例患者出现血肿扩大,362例患者出现不良结局。

平均心率 (HR) 与不良功能结局之间的关联

平均HR增加与不利结局线性相关(每增加10 bpm调整比值比[aOR]为1.31,95%CI为1.14-1.50),但与血肿扩大无关,而HR-ARV与血肿扩大(aOR为1.06,95%CI为1.01-1.12)和不利结局(aOR为1.07,95%CI为1.01-1.3)相关。平均HR每增加10 bpm,不良结局的发生概率增加4.3%,而HR-ARV每增加1,血肿扩大的发生概率增加1.1%,不良结局的发生概率增加1.3%。
 
由此可见,急性ICH初始24小时内平均HR和HR-ARV的增加与不良结局独立相关。此外,HR-ARV与24小时血肿扩大相关。

原始出处:

Kaori Miwa.et al.Effect of Heart Rate Variabilities on Outcome After Acute Intracerebral Hemorrhage: A Post Hoc Analysis of ATACH‐2.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.020364

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    2021-08-16 小桥

    受益匪浅

    0

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    2021-08-16 zhaohui6731
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    2021-08-15 qingbao2004

    学习了

    0

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    2021-08-14 1221f8a5m01(暂无昵称)

    非常棒🌹🌹🌹

    0

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