Fertil Steril:胚泡移植前糖皮质激素和抗菌药物使用对妊娠率有何影响?

2017-06-26 顾歆纯 吴星 环球医学

2017年6月,发表在《Fertil Steril》的一项由美国科学家进行的回顾性队列研究,考察了胚泡移植(ET)前糖皮质激素和抗菌药物使用的结局。

2017年6月,发表在《Fertil Steril》的一项由美国科学家进行的回顾性队列研究,考察了胚泡移植(ET)前糖皮质激素和抗菌药物使用的结局。

目的:评价ET周期围着床期使用和不使用糖皮质激素和口服抗菌药的临床妊娠率。

设计:回顾性队列研究。

地点:大学附属体外受精(IVF)诊所。

患者:876例日常使用或不使用甲基强的松龙和多西环素的接受ETs的患者。

干预:胚胎移植术。

主要结局测量指标:临床妊娠率(CPR)。

结果:日常使用甲基强的松龙和多西环素患者的CPR为56.1%,与之相比,中断这些药物后的CPR为61.5%。使用药物的持续妊娠率为49.5% vs不使用药物的持续妊娠率为53.2%。在卵裂期胚胎中,79%经历辅助孵化;其中,糖皮质激素和抗菌药物治疗的CPR为28.7%,相比没有使用药物组的CPR为47.4%。

结论:常规围着床期糖皮质激素和抗菌药物中断后,总IVF结局无显着统计学差异。这些药物的使用在全国各不相同,或许该结果受到习惯而非基于证据的药物影响。

原始出处:

Kaye L, Bartels C, et al. Old habits die hard: retrospective analysis of outcomes with use of corticosteroids and antibiotics before embryo transfer. Fertil Steril. 2017 Jun;107(6):1336-1340. doi: 10.1016/j.fertnstert.2017.04.003.

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    2017-06-28 lhlxtx
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