ASH 2014:年轻2型糖尿病患者常出现迷走神经活性降低

2014-05-21 高晓方 译 医学论坛网

美国高血压学会年会(ASH 2014)公布的一项研究表明,2型糖尿病青年患者较常表现出与血糖控制不佳相关的迷走神经活性降低。此项研究共纳入86例2型糖尿病患者(平均年龄17.2+3.3岁)和196例对照者(一半的受试者肥胖,平均BMI为30.7 kg/m2),并在基线和4.8年后测定血压、空腹血糖和体力活动等指标。利用SphygmoCor装置测定时域(RMSSD)和频域(LF/HF)心率变异性(H

美国高血压学会年会(ASH 2014)公布的一项研究表明,2型糖尿病青年患者较常表现出与血糖控制不佳相关的迷走神经活性降低。

此项研究共纳入86例2型糖尿病患者(平均年龄17.2+3.3岁)和196例对照者(一半的受试者肥胖,平均BMI为30.7 kg/m2),并在基线和4.8年后测定血压、空腹血糖和体力活动等指标。利用SphygmoCor装置测定时域(RMSSD)和频域(LF/HF)心率变异性(HRV)。通过配对t检验评估协变量和HRV测定差异,并通过广义线性模型确定HRV显著预测因素。

结果显示,与对照者相比,2型糖尿病患者血压较高,不良实验室检测指标较多,并且体重较大(P值均≤0.05)。

2型糖尿病患者的RMSSD较低并且LF/HF比较高,提示迷走神经活性降低(P<0.001)。

RMSSD的决定因素为种族、性别、2型糖尿病、基线糖化血红蛋白水平和体力活动改变;LF/HF的决定因素为种族、基线收缩压、HDL和CRP变化以及HbA1c基线值和变化。

在伴2型糖尿病的青少年和年轻成人中,迷走神经活性降低较为显著,并且血糖控制和体力活动为主要决定因素。改善体力活动和血糖控制的策略有助于避免心脏自主神经病变发生。

原始出处:

Elaine M. Urbina†, Zhiqian Gao, Philip R. Khoury, Amy S. Shah, Thomas R. Kimball, Lawrence M. Dolan.Deterioration in glycemic control & physical activity predict early parasympathetic withdrawal in adolescents & young adults with T2DM.Journal of the American Society of Hypertension.Volume 8, Issue 4, Supplement , Page e16, April 2014


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    2015-04-11 x35042875

    国真实妊娠糖尿病患病率应该在这两种方案得到的患病率之间

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    2014-05-23 kksonne
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