Neurology:ASPECTS评分和CT灌注哪一个更**?

2017-11-30 杨中华 首都医科大学附属北京天坛医院

作者 杨中华  首都医科大学附属北京天坛医院 大面积梗死的患者经过再灌注治疗往往预后不良,甚至再灌注性水肿或出血。ASPECTS评分是一项10分评分系统,评价平扫脑CT预先设定前循环区域的脑实质低密度作为早期缺血性特征。在几项大型急性缺血性卒中血管内治疗的随机临床试验中,采用这项评分标准作为影像学纳入标准。ASPECTS评分能够识别哪些急性缺血性卒中能够从再灌注治疗中获益,或有害。

作者 杨中华  首都医科大学附属北京天坛医院

大面积梗死的患者经过再灌注治疗往往预后不良,甚至再灌注性水肿或出血。ASPECTS评分是一项10分评分系统,评价平扫脑CT预先设定前循环区域的脑实质低密度作为早期缺血性特征。在几项大型急性缺血性卒中血管内治疗的随机临床试验中,采用这项评分标准作为影像学纳入标准。ASPECTS评分能够识别哪些急性缺血性卒中能够从再灌注治疗中获益,或有害。

为了对比ASPECTS评分和CT灌注对急性前循环梗死大小的预测准确性,2017年6月来自澳大利亚的Jelle Demeestere等在Neurology上发表了他们的研究结果。

该观察性研究共纳入了59例急性前循环缺血性卒中的患者,这些患者都进行了平扫CT、灌注CT检查,并且CT扫描100min之内进行了MRI检查。

A图:ASPECTS 5分,CT灌注核心体积58ml(红色为核心、绿色为半暗带),DWI体积106ml三者的一致性:




B图:ASPECTS 9分,CT灌注核心体积52ml(红色为核心、绿色为半暗带),DWI体积90ml三者的一致性:





他们发现平均ASPECTS评分未8分(IQR 5-9)。平均CT灌注核心体积为22ml (IQR 10.4-71.9)。平均MRI DWI病灶体积为24.5ml (IQR 10-63.9)。CT灌注和ASPECTS评分的精确性没有显著性差异(c statistic 0.95 vs 0.87, p value for difference = 0.17)。DWI病灶体积>=70ml的最佳ASPECTS评分cutoff值为<7(敏感性0.74,特异性0.86,Youden J = 0.6),最佳CT灌注核心体积cutoff值为>=50ml(敏感性0.86,特异性0.97,Youden J = 0.84)。

最终作者认为对于预测急性缺血性卒中超急性期MRI病灶体积,CT灌注和ASPECTS评分的精确性没有差异。

文献出处

Two Paradigms for Endovascular Thrombectomy After Intravenous Thrombolysis for Acute Ischemic Stroke. JAMA Neurol. 2017 May 1;74(5):549-556. doi: 10.1001/jamaneurol.2016.5823.


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    2018-08-25 yinhl1978
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Nov 30 13:38:44 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265675, encodeId=64002656e562, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Nov 30 13:03:49 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265636, encodeId=a02f26563643, content=有没有核磁灌注的相关研究呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/307d9bcc1c5effc013c50df76dfd3a91.jpg, createdBy=55fb2211505, createdName=emuboy, createdTime=Thu Nov 30 11:18:11 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-12-08 wl1122050

    不错.可以借鉴学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1647746, encodeId=1345164e746ba, content=<a href='/topic/show?id=883828e714' target=_blank style='color:#2F92EE;'>#ASPECTS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2877, encryptionId=883828e714, topicName=ASPECTS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d23475396, createdName=liye789132259, createdTime=Mon Feb 19 05:15:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000202, encodeId=42dc20002022e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Nov 30 13:38:44 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265675, encodeId=64002656e562, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Nov 30 13:03:49 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265636, encodeId=a02f26563643, content=有没有核磁灌注的相关研究呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/307d9bcc1c5effc013c50df76dfd3a91.jpg, createdBy=55fb2211505, createdName=emuboy, createdTime=Thu Nov 30 11:18:11 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-12-03 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Nov 30 13:38:44 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265675, encodeId=64002656e562, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Nov 30 13:03:49 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265636, encodeId=a02f26563643, content=有没有核磁灌注的相关研究呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/307d9bcc1c5effc013c50df76dfd3a91.jpg, createdBy=55fb2211505, createdName=emuboy, createdTime=Thu Nov 30 11:18:11 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-12-02 docwu2019
  7. 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level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/307d9bcc1c5effc013c50df76dfd3a91.jpg, createdBy=55fb2211505, createdName=emuboy, createdTime=Thu Nov 30 11:18:11 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-11-30 1ddf0692m34(暂无匿称)

    学习了.好文章

    0

  8. 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topicList=[TopicDto(id=5438, encryptionId=10bf5438bc, topicName=CTS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Dec 02 01:15:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265707, encodeId=8b26265e0702, content=学习了.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 30 15:38:43 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265688, encodeId=5b382656887d, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Nov 30 13:38:44 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265675, encodeId=64002656e562, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Nov 30 13:03:49 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265636, encodeId=a02f26563643, content=有没有核磁灌注的相关研究呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/307d9bcc1c5effc013c50df76dfd3a91.jpg, createdBy=55fb2211505, createdName=emuboy, createdTime=Thu Nov 30 11:18:11 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-11-30 Y—xianghai

    学习了新知识

    0

  9. 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topicList=[TopicDto(id=5438, encryptionId=10bf5438bc, topicName=CTS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Dec 02 01:15:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265707, encodeId=8b26265e0702, content=学习了.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 30 15:38:43 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265688, encodeId=5b382656887d, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Nov 30 13:38:44 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265675, encodeId=64002656e562, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Nov 30 13:03:49 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265636, encodeId=a02f26563643, content=有没有核磁灌注的相关研究呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/307d9bcc1c5effc013c50df76dfd3a91.jpg, createdBy=55fb2211505, createdName=emuboy, createdTime=Thu Nov 30 11:18:11 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-11-30 惠映实验室

    学习了.谢谢.

    0

  10. 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level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/307d9bcc1c5effc013c50df76dfd3a91.jpg, createdBy=55fb2211505, createdName=emuboy, createdTime=Thu Nov 30 11:18:11 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-11-30 emuboy

    有没有核磁灌注的相关研究呢

    0

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背景:关于阻塞性睡眠呼吸暂停(OSA)和卒中位置的关系的文献报道结果不一致。研究者旨在急性缺血性卒中患者中,确定卒中位置和OSA的发生的关系;OSA的严重程度由睡眠呼吸暂停低通气指数(AHI),醒来的次数及缺氧检测和中枢和阻塞性肺疾病的发生来确定。方法:数据来源于一项进行OSA诊断和治疗的有效性评估的随机对照试验,这些患者患有急性缺血性卒中和短暂性脑缺血发作。根据脑影像学报告确定卒中位置:皮层下,

这个脑梗死有特点:急性对称性小脑中脚梗死一例

61岁男性,因“言语不清伴左侧肢体无力20余天”入院。患者表现为耳聋、言语不清、眩晕不敢睁眼。既往有高血压、糖尿病、心房颤动病史及大量吸烟、饮酒病史。

Radiology:内囊梗死和脑桥梗死的结构改变和结构功能性代偿的不同模式

内囊是大脑皮层与脑干、脊髓联系的神经纤维通过的一个部位的名称,位于基底神经节与丘脑之间。通往大脑皮层的运动神经纤维和感觉神经纤维,均经内囊向上呈扇形放射状分布。肌紧张和肌肉运动是由脑干网状结构控制的。脑桥网状核是网状结构易化区域之一。脑桥的被盖和延髓网状结构背外侧部、中脑中央灰质以及下丘脑后部和丘脑中缝核群等共同对同侧伸肌起调节作用,主要是易化性影响。另外,在大脑-脑桥-小脑之间形成一个环形联系,