Eur Radiol:FDG-PET/MRI联合DWI检出头颈部鳞状细胞癌放化疗后局部复发的价值

2017-08-26 shaosai MedSci原创

鳞状细胞癌(squamous cell carcinoma)简称鳞癌,为第2个最常见的皮肤恶性肿瘤,起源于皮肤表皮及其附属器(毛囊漏斗、皮脂腺导管、末端汗管) 角质形成细胞,好发于头皮、面部、颈和手背等暴露部位。早期即可呈溃疡,又常继发于慢性溃疡或慢性窦道开口,或瘢痕部的溃疡经久不愈而癌变。临床可呈菜花状,边缘隆起不规则,底部不平,易出血,常伴感染致恶臭。可有局部浸润及区域淋巴结转移。本研究旨在验

鳞状细胞癌(squamous cell carcinoma)简称鳞癌,为第2个最常见的皮肤恶性肿瘤,起源于皮肤表皮及其附属器(毛囊漏斗、皮脂腺导管、末端汗管) 角质形成细胞,好发于头皮、面部、颈和手背等暴露部位。早期即可呈溃疡,又常继发于慢性溃疡或慢性窦道开口,或瘢痕部的溃疡经久不愈而癌变。临床可呈菜花状,边缘隆起不规则,底部不平,易出血,常伴感染致恶臭。可有局部浸润及区域淋巴结转移。本研究旨在验证FDG-PET/MRI联合DWI(FDG-PET/DWIMRI)检出和分级头颈部鳞状细胞癌(HNSCC)放化疗后局部复发的价值,并将结果发表在Eur Radiol上。

本研究前瞻性纳入了74例有HNSCC放化疗史并临床怀疑出现肿瘤复发或放疗并发症的患者,并行PET/MRI检出和形态学MRI、DWI和FDG-PET。有经验地阅片者对临床和组织病理学结果未知,并根据诊断标准对图像进行分析,诊断标准综合了多参数信息的互补性。主要以大体标本的组织病理学和≥24月的随访结果为参考标准。统计分析考虑数据聚类。

诊断依据涵盖了46/74(62.2%)具有组织病理学结果和28/74 (37.8%)具有随访结果(mean ± SD = 34±8 月)。38例患者患有HNSCC,46例患者(10具有肿瘤,36例无肿瘤性病变)具有62处良性病变或并发症。每一位患者PET/DWIMRI的敏感性、特异性、阳性预测值和异性预测值分别为97.4%,91.7%, 92.5%和97.1%;每一处病变PET/DWIMRI的敏感性、特异性、阳性预测值和异性预测值分别为93.0%,93.5%,90.9%和95.1%。影像学结果和病理T分期之间的一致性很好(kappa=0.84, p<0.001)。

本研究表明,FDG-PET/DWIMRI在发现放化疗后HNSCC和对其T分期具有很好的优势。

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1978550, encodeId=a41d19e8550a6, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu Feb 15 11:24:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726675, encodeId=15291e2667556, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Wed Aug 30 00:39:26 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287900, encodeId=dcfb128e900fb, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278709, encodeId=1aa112e87094a, content=<a href='/topic/show?id=c3026349f4' target=_blank style='color:#2F92EE;'>#DWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6349, encryptionId=c3026349f4, topicName=DWI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297685, encodeId=39fe129e68558, content=<a href='/topic/show?id=f999444352f' target=_blank style='color:#2F92EE;'>#头颈部鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44435, encryptionId=f999444352f, topicName=头颈部鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405747, encodeId=d17c1405e470c, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-30 大爰

    学习并分享!!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1978550, encodeId=a41d19e8550a6, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Thu Feb 15 11:24:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726675, encodeId=15291e2667556, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Dec 02 15:24:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787087, encodeId=8f6c1e870876f, content=<a href='/topic/show?id=e1d6140845e' target=_blank style='color:#2F92EE;'>#PET/MRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14084, encryptionId=e1d6140845e, topicName=PET/MRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Aug 12 08:24:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928280, encodeId=5b6119282809d, content=<a href='/topic/show?id=c2b04e602af' target=_blank style='color:#2F92EE;'>#局部复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47602, encryptionId=c2b04e602af, topicName=局部复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Tue Apr 10 12:24:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238633, encodeId=a7bb23863399, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Aug 30 10:28:07 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238470, encodeId=4ecc2384e02e, content=学习过了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Wed Aug 30 00:39:26 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287900, encodeId=dcfb128e900fb, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278709, encodeId=1aa112e87094a, content=<a href='/topic/show?id=c3026349f4' target=_blank style='color:#2F92EE;'>#DWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6349, encryptionId=c3026349f4, topicName=DWI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297685, encodeId=39fe129e68558, content=<a href='/topic/show?id=f999444352f' target=_blank style='color:#2F92EE;'>#头颈部鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44435, encryptionId=f999444352f, topicName=头颈部鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405747, encodeId=d17c1405e470c, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-30 明天会更好!

    学习过了.谢谢分享!

    0

  7. 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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Wed Aug 30 00:39:26 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287900, encodeId=dcfb128e900fb, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278709, encodeId=1aa112e87094a, content=<a href='/topic/show?id=c3026349f4' target=_blank style='color:#2F92EE;'>#DWI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6349, encryptionId=c3026349f4, topicName=DWI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297685, encodeId=39fe129e68558, content=<a href='/topic/show?id=f999444352f' target=_blank style='color:#2F92EE;'>#头颈部鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44435, encryptionId=f999444352f, topicName=头颈部鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405747, encodeId=d17c1405e470c, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Aug 28 14:24:00 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-28 yzh399
  8. 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    2017-08-28 hyf028
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    2017-08-28 chg122

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