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Oncogene：为什么内脏脂肪会增加癌症风险？

2017-08-26 海北 MedSci原创

内脏脂肪肥胖癌症
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已有的流行病学研究显示，多余的脂肪组织会增加癌症的风险。而现在我们正处于全球肥胖患病率急剧上升的时期，但是我们对肥胖如何帮助细胞转化（非致瘤性细胞发生恶化的阶段）还知之甚少。

已有的流行病学研究显示，多余的脂肪组织会增加癌症的风险。而现在我们正处于全球肥胖患病率急剧上升的时期，但是我们对肥胖如何帮助细胞转化（非致瘤性细胞发生恶化的阶段）还知之甚少。 为了探索脂肪组织刺激转化的因素，来自密歇根州立大学的研究人员使用了一种新型的内脏脂肪组织条件培养基刺激上皮细胞在琼脂中生长的体外模型。为了扩展该系统的体内应用，研究人员使用了紫外线B诱导，内脏脂肪促进的小鼠脂质切除皮肤肿瘤模型。 研究人员发现，来自小鼠和肥胖人类的内脏脂肪能够促进非致瘤性上皮细胞在软琼脂中的生长。内脏脂肪组织的活性和成纤维细胞生长因子-2（FGF2）水平有关。人和小鼠的内脏脂肪在缺乏FGFR-1（FGF2受体）的细胞中未能刺激其在软琼脂中的生长。研究人员还证明了FGF2的循环水平与体内非黑色素肿瘤形成有关。 这些数据表明FGF2作为内脏脂肪组织释放的转化上皮细胞的主要因子，是一种全新的内脏组织促进肿瘤发生的潜在途径。消耗内脏脂肪组织中的FGF2或是在腹部肥胖个体中抑制FGFR-1，可能是重要的癌症预防策略以及改善结果的辅助治疗手段。 原始出处： D Chakraborty et al. 

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    2017-11-09 cy0324

    #Gene#

    0

  2. 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    2017-08-28 皇家小娴

    赞!减肥

    0

  3. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-28 inter158

    FGF2作为内脏脂肪组织释放的转化上皮细胞的主要因子.是一种全新的内脏组织促进肿瘤发生的潜在途径.

    0

  4. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Aug 27 00:32:55 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237504, encodeId=487423e50489, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Aug 26 23:47:36 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237412, encodeId=6f5123e412ea, content=要减肥哟!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/03/19/68358be9323aa8e32edd53bfd17742f1.jpg, createdBy=5a191960665, createdName=1e135751m36(暂无匿称), createdTime=Sat Aug 26 15:44:44 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237377, encodeId=5a4823e37700, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Aug 26 12:51:54 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237371, encodeId=0e9823e371a0, content=超厉害的说.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-27 zsyan

    #Oncogene#

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-27 随梦飞扬

    成纤维细胞生长因子-2(FGF2)

    0

  6. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Aug 27 00:32:55 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237504, encodeId=487423e50489, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Aug 26 23:47:36 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237412, encodeId=6f5123e412ea, content=要减肥哟!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-27 明天会更好！

    很不错的.学习了谢谢分享!

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 luominglian113

    学习了.谢谢分享

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Aug 27 00:32:55 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237504, encodeId=487423e50489, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Aug 26 23:47:36 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237412, encodeId=6f5123e412ea, content=要减肥哟!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/03/19/68358be9323aa8e32edd53bfd17742f1.jpg, createdBy=5a191960665, createdName=1e135751m36(暂无匿称), createdTime=Sat Aug 26 15:44:44 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237377, encodeId=5a4823e37700, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Aug 26 12:51:54 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237371, encodeId=0e9823e371a0, content=超厉害的说.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 1e135751m36(暂无匿称)

    要减肥哟!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2048895, encodeId=0a4e2048895cd, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Thu Nov 09 04:34:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238016, encodeId=c93423801611, content=赞!减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/28/527d04919d659f42276a8fe5257991a1.jpg, createdBy=ea152133261, createdName=皇家小娴, createdTime=Mon Aug 28 13:32:40 CST 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 三生有幸9135

    学习一下谢谢分享

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Aug 26 12:45:56 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 戒馋，懒，贪

    超厉害的说.谢谢分享

    0

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背景和目的：我们以前发现，内脏脂肪是比BMI更强大的心血管疾病的危险因素预测指标。调查老年男性和女性糖尿病患病率与客观评估的内脏脂肪量的关系。方法：该队列包括一个以人群为基础的样本（705名男性和688名女性），所有参与者在70岁时进行检查。使用多变量调整后的统计模型评估身体脂肪、血浆葡萄糖水平和糖尿病患病率之间的关联。结果：男性和女性2型糖尿病的患病率分别为14.6%和9.1%(p < 0

J Hypertens：内脏脂肪越多，高血压前期转化成血压正常越难！

这是第一个前瞻性研究表明通过CT扫描确定的体脂分布在预测高血压前期的自然病史中的作用。基础VAT与转化为正常血压呈独立的负相关。没有其他显著的脂肪变量。负责这些观察现象的机制仍有待阐明。