J Hypertens:内脏脂肪越多,高血压前期转化成血压正常越难!

2017-05-21 xing.T MedSci原创

这是第一个前瞻性研究表明通过CT扫描确定的体脂分布在预测高血压前期的自然病史中的作用。基础VAT与转化为正常血压呈独立的负相关。没有其他显著的脂肪变量。负责这些观察现象的机制仍有待阐明。

高血压前期与高血压发生的风险增加有关。然而,很少有关于高血压前期向血压正常转换情况如何,并且哪些变量可以预测这种转换。近日,高血压领域权威杂志Journal of Hypertension上针对这些问题发表了一篇研究文章。

研究人员确定了186名高血压前期的日裔美国人(110名男性,76名女性),年龄为34岁-75岁(平均年龄52.3岁),他们在招募入研究后随访了5年和10年。采用水银血压计测量了血压,计算平均血压。经计算机断层扫描测量了皮下脂肪组织、内脏脂肪组织(VAT)和皮下大腿脂肪组织面积。

在10年的随访中,大约有三分之一的高血压前期患者转化为正常血压。那些转为正常血压的个人较为年轻,较少肥胖,并有显著较低的基础收缩压、空腹血糖、胆固醇水平和稳态模型评估的胰岛素抵抗,相比于那些持续高血压前期后进展为高血压的研究参与者。关于身体脂肪的分布,转化为正常血压的研究参与者相比于非转化者VAT面积显著较小(P<0.001  );但是,皮下脂肪组织和皮下大腿脂肪组织均不显著。在多因素Logistic回归分析中,基础VAT与转换成负相关,并独立于年龄、性别、腰围、糖尿病、空腹血糖、稳态模型评估的胰岛素抵抗、非高密度脂蛋白胆固醇和收缩压[VAT每增加1SD的比值比(95%可信区间)为0.35(0.15-0.80),P=0.012]。

这是第一个前瞻性研究表明通过CT扫描确定的体脂分布在预测高血压前期的自然病史中的作用。基础VAT与转化为正常血压呈独立的负相关。没有其他显著的脂肪变量。负责这些观察现象的机制仍有待阐明。

原始出处:

Hwang, You-Cheo.et al. Greater visceral abdominal fat is associated with a lower probability of conversion of prehypertension to normotension.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/2017/06000/Greater_visceral_abdominal_fat_is_associated_with.13.aspx

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    2017-12-01 2401

    体重及BMI值正常的人其内脏脂肪含量有可能高于正常值吗?如果脂肪含量影响血压.是否运动减肥可以有效预防高血压?

    0

  4. 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    2017-06-03 jyzxjiangqin

    高血压及高血脂相互影响。

    0

  6. 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    2017-05-27 惠映实验室

    高血压前期,可以认为有些是假性高血压,可以在干预下变成正常血压。

    0

  7. 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createdName=xiaoyeshuang, createdTime=Fri Jan 19 09:31:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265894, encodeId=3ff526589499, content=体重及BMI值正常的人其内脏脂肪含量有可能高于正常值吗?如果脂肪含量影响血压.是否运动减肥可以有效预防高血压?, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eopsSZ2rTiaicEtRzAP72y0fNpyt8Q32mRxMKuSfoIibUTmWn9iakiawqyblUKlyrnwNGe9eicuRc2aWCLg/132, createdBy=5de92114919, createdName=2401, createdTime=Fri Dec 01 09:06:11 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038650, encodeId=c3d5203865048, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Jul 26 15:31:00 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205861, encodeId=a941205861eb, content=高血压及高血脂相互影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Jun 03 07:25:59 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202980, encodeId=e7bf202980e5, content=高血压前期,可以认为有些是假性高血压,可以在干预下变成正常血压。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 27 00:29:08 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201862, encodeId=fb8b201862d6, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 24 06:35:32 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490842, encodeId=bc771490842c5, content=<a href='/topic/show?id=ead91026621c' target=_blank style='color:#2F92EE;'>#高血压前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102662, encryptionId=ead91026621c, topicName=高血压前期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1448837648, createdName=kord1985, createdTime=Tue May 23 01:31:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201290, encodeId=c6542012902b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Mon May 22 16:31:29 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201252, encodeId=57a2201252ef, content=新的研究成果,应当重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 22 13:58:28 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-24 大爰

    学习并分享!!

    0

  8. 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topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Jul 26 15:31:00 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205861, encodeId=a941205861eb, content=高血压及高血脂相互影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Jun 03 07:25:59 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202980, encodeId=e7bf202980e5, content=高血压前期,可以认为有些是假性高血压,可以在干预下变成正常血压。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 27 00:29:08 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201862, encodeId=fb8b201862d6, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 24 06:35:32 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490842, encodeId=bc771490842c5, content=<a href='/topic/show?id=ead91026621c' target=_blank 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GetPortalCommentsPageByObjectIdResponse(id=201252, encodeId=57a2201252ef, content=新的研究成果,应当重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 22 13:58:28 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
  9. 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style='color:#2F92EE;'>#高血压前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102662, encryptionId=ead91026621c, topicName=高血压前期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1448837648, createdName=kord1985, createdTime=Tue May 23 01:31:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201290, encodeId=c6542012902b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Mon May 22 16:31:29 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201252, encodeId=57a2201252ef, content=新的研究成果,应当重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 22 13:58:28 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 lou.minghong

    学习

    0

  10. 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topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Wed Jul 26 15:31:00 CST 2017, time=2017-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205861, encodeId=a941205861eb, content=高血压及高血脂相互影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Jun 03 07:25:59 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202980, encodeId=e7bf202980e5, content=高血压前期,可以认为有些是假性高血压,可以在干预下变成正常血压。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 27 00:29:08 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201862, encodeId=fb8b201862d6, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed May 24 06:35:32 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490842, encodeId=bc771490842c5, content=<a href='/topic/show?id=ead91026621c' target=_blank style='color:#2F92EE;'>#高血压前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102662, encryptionId=ead91026621c, topicName=高血压前期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1448837648, createdName=kord1985, createdTime=Tue May 23 01:31:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201290, encodeId=c6542012902b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Mon May 22 16:31:29 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201252, encodeId=57a2201252ef, content=新的研究成果,应当重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 22 13:58:28 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 惠映实验室

    新的研究成果,应当重视

    0

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