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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis
Min Shao, Haipeng Cheng, Xiaohong Li, Yujia Qiu, Yunna Zhang, Yanfen Chang, Jiafeng Fu, Mengxia Shen, Xinxin Xu, Dandan Feng, Yang Han, ShaoJie Yue, Yan Zhou, Ziqiang Luo
Theranostics 2024; 14(7): 2687-2705. doi:10.7150/thno.94072
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Research Paper
Albumin-seeking dyes with adjustable assemblies in situ enable programmable imaging windows and targeting tumor imaging
Yijing Du, Jiajun Xu, Tianyang Han, Zijian Jiang, Yuewei Zhang, Jia Li, Xiaoyuan Chen, Shoujun Zhu
Theranostics 2024; 14(7): 2675-2686. doi:10.7150/thno.92991
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Research Paper
AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia
Niels Vandewalle, Hatice Satilmis, Emma Verheye, Rong Fan, Yanmeng Wang, Timo W.M. De Groof, Jessica Bridoux, Tessa Kerre, Nathan De Beule, Ann De Becker, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Karine Breckpot, Nick Devoogdt, Kim De Veirman
Theranostics 2024; 14(7): 2656-2674. doi:10.7150/thno.91456
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Research Paper
Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia
Jing Liu, Weiwei Wu, Fei Peng, Deying Gong, Yi Kang, Yujun Zhang, Congyan Liu, Yuncheng Li, Guoyan Zhao, Feng Qiu, Wensheng Zhang
Theranostics 2024; 14(6): 2637-2655. doi:10.7150/thno.93322
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Research Paper
NAD+ precursors promote the restoration of spermatogenesis in busulfan-treated mice through inhibiting Sirt2-regulated ferroptosis
Yan-Qin Feng, Xuan Liu, Ning Zuo, Mu-Bin Yu, Wen-Meng Bian, Bao-Quan Han, Zhong-Yi Sun, Massimo De Felici, Wei Shen, Lan Li
Theranostics 2024; 14(6): 2622-2636. doi:10.7150/thno.92416
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Research Paper
IL4 receptor targeting enables nab-paclitaxel to enhance reprogramming of M2-type macrophages into M1-like phenotype via ROS-HMGB1-TLR4 axis and inhibition of tumor growth and metastasis
Sri Murugan Poongkavithai Vadevoo, Yeoul Kang, Gowri Rangaswamy Gunassekaran, Seok-Min Lee, Min-Sung Park, Dong Gyun Jo, Sang-Kyun Kim, Ho Lee, Won Jong Kim, Byungheon Lee
Theranostics 2024; 14(6): 2605-2621. doi:10.7150/thno.92672
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Research Paper
Siglec-F+ neutrophils in the spleen induce immunosuppression following acute infection
Chaoxiong Liao, Shuhua Luo, Xiaolei Liu, Lina Zhang, Pengyun Xie, Wending Zhou, Yue Lu, Hanhui Zhong, Xuedi Zhang, Ziying Xiong, Xiao Huang, Guixi Mo, Daqing Ma, Jing Tang
Theranostics 2024; 14(6): 2589-2604. doi:10.7150/thno.93812
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Research Paper
Hypofractionated radiotherapy combined with lenalidomide improves systemic antitumor activity in mouse solid tumor models
Kateryna Onyshchenko, Ren Luo, Xi Rao, Xuanwei Zhang, Simone Gaedicke, Anca-Ligia Grosu, Elke Firat, Gabriele Niedermann
Theranostics 2024; 14(6): 2573-2588. doi:10.7150/thno.88864
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

CFP - Special issue on Molecular Imaging and Theranostics. Guest Editors: Dr. Jianhua Zou, Dr. Jingjing Zhang and Dr. Mengyao Zhao.

Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.

Background: Hypofractionated radiotherapy (hRT) can induce a T cell-mediated abscopal effect on non-irradiated tumor lesions, especially in combination with immune checkpoint blockade (ICB). However, clinically, this effect is still rare, and ICB-mediated adverse events are common. Lenalidomide (lena) is an anti-angiogenic and immunomodulatory drug used in the treatment of hematologic malignancies. We here investigated in solid tumor models whether lena can enhance the abscopal effect in double combination with hRT. Methods: In two syngeneic bilateral tumor models (B16-CD133 melanoma and MC38 colon....
Rationale: Nab-paclitaxel (Abx) is widely employed in malignant tumor therapy. In tumor cells and pro-tumoral M2-type macrophages, the IL4 receptor (IL4R) is upregulated. This study aimed to elucidate the selective delivery of Abx to M2-type macrophages by targeting IL4R and reprogramming them into an anti-tumoral M1-type. Methods: Abx was conjugated with the IL4R-binding IL4RPep-1 peptide using click chemistry (IL4R-Abx). Cellular internalization, macrophage reprogramming and signal pathways, and tumor growth and metastasis by IL4R-Abx were examined. Results: IL4R-Abx was internalized into M2....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Review
Knockout cancer by nano-delivered immunotherapy using perfusion-aided scaffold-based tumor-on-a-chip
Pooja Suryavanshi, Dhananjay Bodas
Nanotheranostics 2024; 8(3): 380-400. doi:10.7150/ntno.87818
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