Development of New Gonadotropin-Releasing Hormone-Modified Dendrimer Platforms with Direct Antiproliferative and Gonadotropin Releasing Activity

Varamini, P; Rafiee, A; Giddam, AK; Mansfeld, FM; Steyn, F; Toth, I

Toth, I (reprint author), Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia.; Toth, I (reprint author), Univ Queensland, Sch Pharm, Woollongabba, Qld 4102, Australia.; Toth, I (reprint author), Univ Queensland, Inst Mol Biosci, Brisban

JOURNAL OF MEDICINAL CHEMISTRY, 2017; 60 (20): 8309

Abstract

Gonadotropin-releasing hormone (GnRH) agonists (e.g., triptorelin) are used for androgen suppression therapy. They possess improved stability as compa......

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