Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders

Yang, JL; Li, YB; Aguilar, A; Liu, ZM; Yang, CY; Wang, SM

Wang, SM (reprint author), Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA.; Wang, SM (reprint author), Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.; Wang, SM (reprint author), Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA.; W

JOURNAL OF MEDICINAL CHEMISTRY, 2019; 62 (21): 9471

Abstract

Inducing protein degradation by proteolysis targeting chimeras (PROTACs) has gained tremendous momentum for its promise to discover and develop new th......

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