Multiple domain interfaces mediate SARM1 autoinhibition

Shen, C; Vohra, M; Zhang, PF; Mao, XR; Figley, MD; Zhu, J; Sasaki, Y; Wu, H; DiAntonio, A; Milbrandt, J

Wu, H (corresponding author), Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.; Wu, H (corresponding author), Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA.; Milbrandt, J (corresponding author), Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.; DiAntonio, A (corresponding author), Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA.; DiAntonio, A; Milbrandt, J (corresponding author), Washington Univ, Sch Med, Needleman Ctr

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (4):

Abstract

Axon degeneration is an active program of self-destruction mediated by the protein SARM1. In healthy neurons, SARM1 is autoinhibited and, upon injury ......

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