Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics

Hu, LP; Zhou, KX; Huo, YM; Liu, DJ; Li, Q; Yang, MW; Huang, PQ; Xu, CJ; Tian, GA; Yao, LL; Zhang, XL; Wang, YH; Li, J; Zhang, ZG; Jiang, SH; Xing, X; Wang, X; Qin, WT; Yang, Q

Wang, X; Qin, WT; Yang, Q (corresponding author), Shanghai Jiao Tong Univ, Ren Ji Hosp, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes,Sch Med, Shanghai, Peoples R China.; Wang, X; Qin, WT; Yang, Q (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Biliary Pancreat Surg, Shanghai, Peoples R China.

ONCOGENESIS, 2021; 10 (3):

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective treatment strategies. There is an urgent need for the d......

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