Single-mutations at the galactose-binding site of enzymes Galk, GalU, and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-d-galactose and azido-functionalized Gb3 analogs

Ortiz-Soto, ME; Baier, M; Brenner, D; Timm, M; Seibel, J

Seibel, J (通讯作者)，Julius Maximilians Univ, Inst Organ Chem, D-97074 Wurzburg, Germany.

GLYCOBIOLOGY, 2023; 33 (8): 651

Abstract

Lysosomal accumulation of the glycosphingolipid globotriaosylceramide Gb3 is linked to the deficient activity of the alpha-galactosidase A in the Ande......

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