QSER1 protects DNA methylation valleys from de novo methylation

Dixon, G; Pan, H; Yang, DP; Rosen, BP; Jashari, T; Verma, N; Pulecio, J; Caspi, I; Lee, K; Stransky, S; Glezer, A; Liu, C; Rivas, M; Kumar, R; Lan, YH; Torregroza, I; He, C; Sidoli, S; Evans, T; Elemento, O; Huangfu, D

Huangfu, D (corresponding author), Sloan Kettering Inst, Dev Biol Program, 1275 York Ave, New York, NY 10065 USA.; Elemento, O (corresponding author), Weill Cornell Med, Inst Computat Biomed, Dept Physiol & Biophys, Englander Inst Precis Med, 1300 York Ave, New York, NY 10065 USA.

SCIENCE, 2021; 372 (6538): 146

Abstract

DNA methylation is essential to mammalian development, and dysregulation can cause serious pathological conditions. Key enzymes responsible for deposi......

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